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A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study

Hyperuricemia has been demonstrated to be a risk factor for cardiovascular diseases. Though the association between uric acid (UA) and arterial stiffness has been investigated previously in patients with basic diseases, the predictive value of baseline UA level for arterial stiffness has not been co...

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Autores principales: Ding, Xiao-Han, Wang, Xiaona, Cao, Ruihua, Yang, Xu, Xiao, Wenkai, Zhang, Yun, Bai, Yongyi, Wu, Hongmei, Ye, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312993/
https://www.ncbi.nlm.nih.gov/pubmed/28178136
http://dx.doi.org/10.1097/MD.0000000000005957
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author Ding, Xiao-Han
Wang, Xiaona
Cao, Ruihua
Yang, Xu
Xiao, Wenkai
Zhang, Yun
Bai, Yongyi
Wu, Hongmei
Ye, Ping
author_facet Ding, Xiao-Han
Wang, Xiaona
Cao, Ruihua
Yang, Xu
Xiao, Wenkai
Zhang, Yun
Bai, Yongyi
Wu, Hongmei
Ye, Ping
author_sort Ding, Xiao-Han
collection PubMed
description Hyperuricemia has been demonstrated to be a risk factor for cardiovascular diseases. Though the association between uric acid (UA) and arterial stiffness has been investigated previously in patients with basic diseases, the predictive value of baseline UA level for arterial stiffness has not been conducted. We aimed at identifying the predictive role of UA for arterial stiffness prospectively. A longitudinal follow-up study in a routine health check-up population was performed with an average follow-up of 4.8 years. The demographic information, baseline and follow-up anthropometric parameters, arterial stiffness (pulse-wave velocity, PWV), and biomarker variables including UA have been measured and analyzed. A total of 1447 valid follow-ups were available for the final analysis. Both of the baseline and follow-up UA levels were significantly higher in the arterial stiffness groups than that in the nonarterial stiffness groups (all P values <0.001). The follow-up carotid-femoral PWV [(cf-PWV), r = 0.161, P < 0.001] was strongly correlated with baseline UA. At the follow-up cross-section, cf-PWV was also closely associated with UA (r = 0.101, P < 0.001). Logistic regressions revealed that a higher baseline UA level was an independent predictor of follow-up arterial stiffness assessed by cf-PWV [odds ratio (OR): 1.824; P = 0.046]. A higher baseline level of UA is closely related to arterial stiffness and is an independent predictor of arterial stiffening.
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spelling pubmed-53129932017-02-21 A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study Ding, Xiao-Han Wang, Xiaona Cao, Ruihua Yang, Xu Xiao, Wenkai Zhang, Yun Bai, Yongyi Wu, Hongmei Ye, Ping Medicine (Baltimore) 3400 Hyperuricemia has been demonstrated to be a risk factor for cardiovascular diseases. Though the association between uric acid (UA) and arterial stiffness has been investigated previously in patients with basic diseases, the predictive value of baseline UA level for arterial stiffness has not been conducted. We aimed at identifying the predictive role of UA for arterial stiffness prospectively. A longitudinal follow-up study in a routine health check-up population was performed with an average follow-up of 4.8 years. The demographic information, baseline and follow-up anthropometric parameters, arterial stiffness (pulse-wave velocity, PWV), and biomarker variables including UA have been measured and analyzed. A total of 1447 valid follow-ups were available for the final analysis. Both of the baseline and follow-up UA levels were significantly higher in the arterial stiffness groups than that in the nonarterial stiffness groups (all P values <0.001). The follow-up carotid-femoral PWV [(cf-PWV), r = 0.161, P < 0.001] was strongly correlated with baseline UA. At the follow-up cross-section, cf-PWV was also closely associated with UA (r = 0.101, P < 0.001). Logistic regressions revealed that a higher baseline UA level was an independent predictor of follow-up arterial stiffness assessed by cf-PWV [odds ratio (OR): 1.824; P = 0.046]. A higher baseline level of UA is closely related to arterial stiffness and is an independent predictor of arterial stiffening. Wolters Kluwer Health 2017-02-10 /pmc/articles/PMC5312993/ /pubmed/28178136 http://dx.doi.org/10.1097/MD.0000000000005957 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 3400
Ding, Xiao-Han
Wang, Xiaona
Cao, Ruihua
Yang, Xu
Xiao, Wenkai
Zhang, Yun
Bai, Yongyi
Wu, Hongmei
Ye, Ping
A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study
title A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study
title_full A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study
title_fullStr A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study
title_full_unstemmed A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study
title_short A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study
title_sort higher baseline plasma uric acid level is an independent predictor of arterial stiffness: a community-based prospective study
topic 3400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312993/
https://www.ncbi.nlm.nih.gov/pubmed/28178136
http://dx.doi.org/10.1097/MD.0000000000005957
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