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A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study
Hyperuricemia has been demonstrated to be a risk factor for cardiovascular diseases. Though the association between uric acid (UA) and arterial stiffness has been investigated previously in patients with basic diseases, the predictive value of baseline UA level for arterial stiffness has not been co...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312993/ https://www.ncbi.nlm.nih.gov/pubmed/28178136 http://dx.doi.org/10.1097/MD.0000000000005957 |
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author | Ding, Xiao-Han Wang, Xiaona Cao, Ruihua Yang, Xu Xiao, Wenkai Zhang, Yun Bai, Yongyi Wu, Hongmei Ye, Ping |
author_facet | Ding, Xiao-Han Wang, Xiaona Cao, Ruihua Yang, Xu Xiao, Wenkai Zhang, Yun Bai, Yongyi Wu, Hongmei Ye, Ping |
author_sort | Ding, Xiao-Han |
collection | PubMed |
description | Hyperuricemia has been demonstrated to be a risk factor for cardiovascular diseases. Though the association between uric acid (UA) and arterial stiffness has been investigated previously in patients with basic diseases, the predictive value of baseline UA level for arterial stiffness has not been conducted. We aimed at identifying the predictive role of UA for arterial stiffness prospectively. A longitudinal follow-up study in a routine health check-up population was performed with an average follow-up of 4.8 years. The demographic information, baseline and follow-up anthropometric parameters, arterial stiffness (pulse-wave velocity, PWV), and biomarker variables including UA have been measured and analyzed. A total of 1447 valid follow-ups were available for the final analysis. Both of the baseline and follow-up UA levels were significantly higher in the arterial stiffness groups than that in the nonarterial stiffness groups (all P values <0.001). The follow-up carotid-femoral PWV [(cf-PWV), r = 0.161, P < 0.001] was strongly correlated with baseline UA. At the follow-up cross-section, cf-PWV was also closely associated with UA (r = 0.101, P < 0.001). Logistic regressions revealed that a higher baseline UA level was an independent predictor of follow-up arterial stiffness assessed by cf-PWV [odds ratio (OR): 1.824; P = 0.046]. A higher baseline level of UA is closely related to arterial stiffness and is an independent predictor of arterial stiffening. |
format | Online Article Text |
id | pubmed-5312993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-53129932017-02-21 A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study Ding, Xiao-Han Wang, Xiaona Cao, Ruihua Yang, Xu Xiao, Wenkai Zhang, Yun Bai, Yongyi Wu, Hongmei Ye, Ping Medicine (Baltimore) 3400 Hyperuricemia has been demonstrated to be a risk factor for cardiovascular diseases. Though the association between uric acid (UA) and arterial stiffness has been investigated previously in patients with basic diseases, the predictive value of baseline UA level for arterial stiffness has not been conducted. We aimed at identifying the predictive role of UA for arterial stiffness prospectively. A longitudinal follow-up study in a routine health check-up population was performed with an average follow-up of 4.8 years. The demographic information, baseline and follow-up anthropometric parameters, arterial stiffness (pulse-wave velocity, PWV), and biomarker variables including UA have been measured and analyzed. A total of 1447 valid follow-ups were available for the final analysis. Both of the baseline and follow-up UA levels were significantly higher in the arterial stiffness groups than that in the nonarterial stiffness groups (all P values <0.001). The follow-up carotid-femoral PWV [(cf-PWV), r = 0.161, P < 0.001] was strongly correlated with baseline UA. At the follow-up cross-section, cf-PWV was also closely associated with UA (r = 0.101, P < 0.001). Logistic regressions revealed that a higher baseline UA level was an independent predictor of follow-up arterial stiffness assessed by cf-PWV [odds ratio (OR): 1.824; P = 0.046]. A higher baseline level of UA is closely related to arterial stiffness and is an independent predictor of arterial stiffening. Wolters Kluwer Health 2017-02-10 /pmc/articles/PMC5312993/ /pubmed/28178136 http://dx.doi.org/10.1097/MD.0000000000005957 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 3400 Ding, Xiao-Han Wang, Xiaona Cao, Ruihua Yang, Xu Xiao, Wenkai Zhang, Yun Bai, Yongyi Wu, Hongmei Ye, Ping A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study |
title | A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study |
title_full | A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study |
title_fullStr | A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study |
title_full_unstemmed | A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study |
title_short | A higher baseline plasma uric acid level is an independent predictor of arterial stiffness: A community-based prospective study |
title_sort | higher baseline plasma uric acid level is an independent predictor of arterial stiffness: a community-based prospective study |
topic | 3400 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312993/ https://www.ncbi.nlm.nih.gov/pubmed/28178136 http://dx.doi.org/10.1097/MD.0000000000005957 |
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