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Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes

Deficiency of glucocerebrosidase (GBA) causes Gaucher disease (GD). In the common non-neuronopathic GD type I variant, glucosylceramide accumulates primarily in the lysosomes of visceral macrophages. Supplementing storage cells with lacking enzyme is accomplished via chronic intravenous administrati...

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Detalles Bibliográficos
Autores principales:	Kallemeijn, Wouter W., Scheij, Saskia, Hoogendoorn, Sascha, Witte, Martin D., Herrera Moro Chao, Daniela, van Roomen, Cindy P. A. A., Ottenhoff, Roelof, Overkleeft, Herman S., Boot, Rolf G., Aerts, Johannes M. F. G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313132/ https://www.ncbi.nlm.nih.gov/pubmed/28207759 http://dx.doi.org/10.1371/journal.pone.0170268

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