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TMG-123, a novel glucokinase activator, exerts durable effects on hyperglycemia without increasing triglyceride in diabetic animal models

Glucokinase (GK) plays a critical role for maintaining glucose homeostasis with regulating glucose uptake in liver and insulin secretion in pancreas. GK activators have been reported to decrease blood glucose levels in patients with type 2 diabetes mellitus. However, clinical development of GK activ...

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Detalles Bibliográficos
Autores principales:	Tsumura, Yoshinori, Tsushima, Yu, Tamura, Azusa, Hasebe, Makiko, Kanou, Masanobu, Kato, Hirotsugu, Kobayashi, Tsunefumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313197/ https://www.ncbi.nlm.nih.gov/pubmed/28207836 http://dx.doi.org/10.1371/journal.pone.0172252

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