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In vitro fertilization outcome in women with diminished ovarian reserve

OBJECTIVE: This study aimed to identify factors that affect in vitro fertilization (IVF) outcomes in women with diminished ovarian reserve (DOR). METHODS: We reviewed 99 IVF cycles in 52 women with DOR between September 2010 and January 2015. DOR was defined as serum anti-Müllerian hormone level of...

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Autores principales: Yun, Bo Hyon, Kim, Gieun, Park, Seon Hee, Noe, Eun Bee, Seo, Seok Kyo, Cho, SiHyun, Choi, Young Sik, Lee, Byung Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2017
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313363/
https://www.ncbi.nlm.nih.gov/pubmed/28217671
http://dx.doi.org/10.5468/ogs.2017.60.1.46
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author Yun, Bo Hyon
Kim, Gieun
Park, Seon Hee
Noe, Eun Bee
Seo, Seok Kyo
Cho, SiHyun
Choi, Young Sik
Lee, Byung Seok
author_facet Yun, Bo Hyon
Kim, Gieun
Park, Seon Hee
Noe, Eun Bee
Seo, Seok Kyo
Cho, SiHyun
Choi, Young Sik
Lee, Byung Seok
author_sort Yun, Bo Hyon
collection PubMed
description OBJECTIVE: This study aimed to identify factors that affect in vitro fertilization (IVF) outcomes in women with diminished ovarian reserve (DOR). METHODS: We reviewed 99 IVF cycles in 52 women with DOR between September 2010 and January 2015. DOR was defined as serum anti-Müllerian hormone level of <1.1 ng/dL or serum follicle-stimulating hormone level of ≥20 mIU/mL. Total 96 cycles in 50 patients were evaluated after excluding fertility preservation cases. RESULTS: The clinical pregnancy rate was 11.5% per cycle, and the total cancellation rate was 34.4%. Clinical pregnancy rate was significantly associated with the antral follicle count and the cause of the DOR. Age, serum anti-Müllerian hormone and follicle-stimulating hormone levels, antral follicle count, peak estradiol level, and the cause of DOR were significantly associated with cycle cancellation. However, history of previous ovarian surgery remained as a significant factor of clinical pregnancy (model 1: odds ratio [OR] 10.17, 95% confidence interval [CI] 1.46 to 70.84, P=0.019; model 2: OR 10.85, 95% CI 1.05 to 111.71, P=0.045). In cancellation models, idiopathic or previous chemotherapy group showed borderline significance (model 1: OR 3.76, 95% CI 0.83 to 17.04, P=0.086; model 2: OR 3.15, 95% CI 0.84 to 11.84, P=0.09). CONCLUSION: DOR caused by previous ovarian surgery may show better pregnancy outcome, whereas that caused by chemotherapy could significantly increase the cycle cancellation rate. Furthermore, patients with DOR who previously received gonadotoxic agents may show reduced efficacy and increased risk of IVF cycle cancellation.
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spelling pubmed-53133632017-02-18 In vitro fertilization outcome in women with diminished ovarian reserve Yun, Bo Hyon Kim, Gieun Park, Seon Hee Noe, Eun Bee Seo, Seok Kyo Cho, SiHyun Choi, Young Sik Lee, Byung Seok Obstet Gynecol Sci Original Article OBJECTIVE: This study aimed to identify factors that affect in vitro fertilization (IVF) outcomes in women with diminished ovarian reserve (DOR). METHODS: We reviewed 99 IVF cycles in 52 women with DOR between September 2010 and January 2015. DOR was defined as serum anti-Müllerian hormone level of <1.1 ng/dL or serum follicle-stimulating hormone level of ≥20 mIU/mL. Total 96 cycles in 50 patients were evaluated after excluding fertility preservation cases. RESULTS: The clinical pregnancy rate was 11.5% per cycle, and the total cancellation rate was 34.4%. Clinical pregnancy rate was significantly associated with the antral follicle count and the cause of the DOR. Age, serum anti-Müllerian hormone and follicle-stimulating hormone levels, antral follicle count, peak estradiol level, and the cause of DOR were significantly associated with cycle cancellation. However, history of previous ovarian surgery remained as a significant factor of clinical pregnancy (model 1: odds ratio [OR] 10.17, 95% confidence interval [CI] 1.46 to 70.84, P=0.019; model 2: OR 10.85, 95% CI 1.05 to 111.71, P=0.045). In cancellation models, idiopathic or previous chemotherapy group showed borderline significance (model 1: OR 3.76, 95% CI 0.83 to 17.04, P=0.086; model 2: OR 3.15, 95% CI 0.84 to 11.84, P=0.09). CONCLUSION: DOR caused by previous ovarian surgery may show better pregnancy outcome, whereas that caused by chemotherapy could significantly increase the cycle cancellation rate. Furthermore, patients with DOR who previously received gonadotoxic agents may show reduced efficacy and increased risk of IVF cycle cancellation. Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2017-01 2017-01-19 /pmc/articles/PMC5313363/ /pubmed/28217671 http://dx.doi.org/10.5468/ogs.2017.60.1.46 Text en Copyright © 2017 Korean Society of Obstetrics and Gynecology http://creativecommons.org/licenses/by-nc/3.0/ Articles published in Obstet Gynecol Sci are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yun, Bo Hyon
Kim, Gieun
Park, Seon Hee
Noe, Eun Bee
Seo, Seok Kyo
Cho, SiHyun
Choi, Young Sik
Lee, Byung Seok
In vitro fertilization outcome in women with diminished ovarian reserve
title In vitro fertilization outcome in women with diminished ovarian reserve
title_full In vitro fertilization outcome in women with diminished ovarian reserve
title_fullStr In vitro fertilization outcome in women with diminished ovarian reserve
title_full_unstemmed In vitro fertilization outcome in women with diminished ovarian reserve
title_short In vitro fertilization outcome in women with diminished ovarian reserve
title_sort in vitro fertilization outcome in women with diminished ovarian reserve
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313363/
https://www.ncbi.nlm.nih.gov/pubmed/28217671
http://dx.doi.org/10.5468/ogs.2017.60.1.46
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