Cargando…
Clinical Outcomes in Diabetic Patients Who Underwent Percutaneous Coronary Intervention during the Plain Old Balloon Angioplasty (POBA)-, Bare Metal Stents (BMS)- and Drug-eluting Stents (DES)-eras from 1984 to 2010
Objective Diabetes is a negative predictor in coronary artery disease patients. Since the introduction of percutaneous coronary intervention (PCI), PCI has evolved through technological advances in devices, improvements in operators' techniques and the establishment of effective therapeutic pro...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313418/ https://www.ncbi.nlm.nih.gov/pubmed/28049984 |
_version_ | 1782508339282837504 |
---|---|
author | Naito, Ryo Miyauchi, Katsumi Konishi, Hirokazu Tsuboi, Shuta Ogita, Manabu Dohi, Tomotaka Kasai, Takatoshi Tamura, Hiroshi Okazaki, Shinya Isoda, Kikuo Daida, Hiroyuki |
author_facet | Naito, Ryo Miyauchi, Katsumi Konishi, Hirokazu Tsuboi, Shuta Ogita, Manabu Dohi, Tomotaka Kasai, Takatoshi Tamura, Hiroshi Okazaki, Shinya Isoda, Kikuo Daida, Hiroyuki |
author_sort | Naito, Ryo |
collection | PubMed |
description | Objective Diabetes is a negative predictor in coronary artery disease patients. Since the introduction of percutaneous coronary intervention (PCI), PCI has evolved through technological advances in devices, improvements in operators' techniques and the establishment of effective therapeutic protocols. The aim of this study is to examine the changes in the clinical outcomes following PCI in patients with diabetes. Methods We compared the clinical outcomes in patients with diabetes following PCI from 1984 to 2010 at Juntendo University over three eras (plain old balloon angioplasty (POBA)-, bare metal stents (BMS)- and drug-eluting stents (DES)-eras). The primary endpoint was a composite of all-cause mortality, non-fatal myocardial infarction, non-fatal stroke and repeat revascularization within 3 years after the index PCI. Results A total of 1,584 patients were examined. The baseline characteristics became unfavorable over time with regard to age, prevalence of hypertension, presentation with acute coronary syndrome and a reduced left ventricular ejection fraction. The administration of aspirin, statins and β-blockers increased over time. The event-free survival rate for the 3-year cardiovascular events was lower in the DES-era. The adjusted relative risk reduction for 3-year cardiovascular events was 46 % in the DES-era compared with the POBA-era. Conclusion The incidence of 3-year cardiovascular events decreased from 1984 to 2010 in patients with diabetes following PCI, despite the higher risk profiles in the DES-era. |
format | Online Article Text |
id | pubmed-5313418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-53134182017-02-28 Clinical Outcomes in Diabetic Patients Who Underwent Percutaneous Coronary Intervention during the Plain Old Balloon Angioplasty (POBA)-, Bare Metal Stents (BMS)- and Drug-eluting Stents (DES)-eras from 1984 to 2010 Naito, Ryo Miyauchi, Katsumi Konishi, Hirokazu Tsuboi, Shuta Ogita, Manabu Dohi, Tomotaka Kasai, Takatoshi Tamura, Hiroshi Okazaki, Shinya Isoda, Kikuo Daida, Hiroyuki Intern Med Original Article Objective Diabetes is a negative predictor in coronary artery disease patients. Since the introduction of percutaneous coronary intervention (PCI), PCI has evolved through technological advances in devices, improvements in operators' techniques and the establishment of effective therapeutic protocols. The aim of this study is to examine the changes in the clinical outcomes following PCI in patients with diabetes. Methods We compared the clinical outcomes in patients with diabetes following PCI from 1984 to 2010 at Juntendo University over three eras (plain old balloon angioplasty (POBA)-, bare metal stents (BMS)- and drug-eluting stents (DES)-eras). The primary endpoint was a composite of all-cause mortality, non-fatal myocardial infarction, non-fatal stroke and repeat revascularization within 3 years after the index PCI. Results A total of 1,584 patients were examined. The baseline characteristics became unfavorable over time with regard to age, prevalence of hypertension, presentation with acute coronary syndrome and a reduced left ventricular ejection fraction. The administration of aspirin, statins and β-blockers increased over time. The event-free survival rate for the 3-year cardiovascular events was lower in the DES-era. The adjusted relative risk reduction for 3-year cardiovascular events was 46 % in the DES-era compared with the POBA-era. Conclusion The incidence of 3-year cardiovascular events decreased from 1984 to 2010 in patients with diabetes following PCI, despite the higher risk profiles in the DES-era. The Japanese Society of Internal Medicine 2017-01-01 /pmc/articles/PMC5313418/ /pubmed/28049984 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Naito, Ryo Miyauchi, Katsumi Konishi, Hirokazu Tsuboi, Shuta Ogita, Manabu Dohi, Tomotaka Kasai, Takatoshi Tamura, Hiroshi Okazaki, Shinya Isoda, Kikuo Daida, Hiroyuki Clinical Outcomes in Diabetic Patients Who Underwent Percutaneous Coronary Intervention during the Plain Old Balloon Angioplasty (POBA)-, Bare Metal Stents (BMS)- and Drug-eluting Stents (DES)-eras from 1984 to 2010 |
title | Clinical Outcomes in Diabetic Patients Who Underwent Percutaneous Coronary Intervention during the Plain Old Balloon Angioplasty (POBA)-, Bare Metal Stents (BMS)- and Drug-eluting Stents (DES)-eras from 1984 to 2010 |
title_full | Clinical Outcomes in Diabetic Patients Who Underwent Percutaneous Coronary Intervention during the Plain Old Balloon Angioplasty (POBA)-, Bare Metal Stents (BMS)- and Drug-eluting Stents (DES)-eras from 1984 to 2010 |
title_fullStr | Clinical Outcomes in Diabetic Patients Who Underwent Percutaneous Coronary Intervention during the Plain Old Balloon Angioplasty (POBA)-, Bare Metal Stents (BMS)- and Drug-eluting Stents (DES)-eras from 1984 to 2010 |
title_full_unstemmed | Clinical Outcomes in Diabetic Patients Who Underwent Percutaneous Coronary Intervention during the Plain Old Balloon Angioplasty (POBA)-, Bare Metal Stents (BMS)- and Drug-eluting Stents (DES)-eras from 1984 to 2010 |
title_short | Clinical Outcomes in Diabetic Patients Who Underwent Percutaneous Coronary Intervention during the Plain Old Balloon Angioplasty (POBA)-, Bare Metal Stents (BMS)- and Drug-eluting Stents (DES)-eras from 1984 to 2010 |
title_sort | clinical outcomes in diabetic patients who underwent percutaneous coronary intervention during the plain old balloon angioplasty (poba)-, bare metal stents (bms)- and drug-eluting stents (des)-eras from 1984 to 2010 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313418/ https://www.ncbi.nlm.nih.gov/pubmed/28049984 |
work_keys_str_mv | AT naitoryo clinicaloutcomesindiabeticpatientswhounderwentpercutaneouscoronaryinterventionduringtheplainoldballoonangioplastypobabaremetalstentsbmsanddrugelutingstentsdeserasfrom1984to2010 AT miyauchikatsumi clinicaloutcomesindiabeticpatientswhounderwentpercutaneouscoronaryinterventionduringtheplainoldballoonangioplastypobabaremetalstentsbmsanddrugelutingstentsdeserasfrom1984to2010 AT konishihirokazu clinicaloutcomesindiabeticpatientswhounderwentpercutaneouscoronaryinterventionduringtheplainoldballoonangioplastypobabaremetalstentsbmsanddrugelutingstentsdeserasfrom1984to2010 AT tsuboishuta clinicaloutcomesindiabeticpatientswhounderwentpercutaneouscoronaryinterventionduringtheplainoldballoonangioplastypobabaremetalstentsbmsanddrugelutingstentsdeserasfrom1984to2010 AT ogitamanabu clinicaloutcomesindiabeticpatientswhounderwentpercutaneouscoronaryinterventionduringtheplainoldballoonangioplastypobabaremetalstentsbmsanddrugelutingstentsdeserasfrom1984to2010 AT dohitomotaka clinicaloutcomesindiabeticpatientswhounderwentpercutaneouscoronaryinterventionduringtheplainoldballoonangioplastypobabaremetalstentsbmsanddrugelutingstentsdeserasfrom1984to2010 AT kasaitakatoshi clinicaloutcomesindiabeticpatientswhounderwentpercutaneouscoronaryinterventionduringtheplainoldballoonangioplastypobabaremetalstentsbmsanddrugelutingstentsdeserasfrom1984to2010 AT tamurahiroshi clinicaloutcomesindiabeticpatientswhounderwentpercutaneouscoronaryinterventionduringtheplainoldballoonangioplastypobabaremetalstentsbmsanddrugelutingstentsdeserasfrom1984to2010 AT okazakishinya clinicaloutcomesindiabeticpatientswhounderwentpercutaneouscoronaryinterventionduringtheplainoldballoonangioplastypobabaremetalstentsbmsanddrugelutingstentsdeserasfrom1984to2010 AT isodakikuo clinicaloutcomesindiabeticpatientswhounderwentpercutaneouscoronaryinterventionduringtheplainoldballoonangioplastypobabaremetalstentsbmsanddrugelutingstentsdeserasfrom1984to2010 AT daidahiroyuki clinicaloutcomesindiabeticpatientswhounderwentpercutaneouscoronaryinterventionduringtheplainoldballoonangioplastypobabaremetalstentsbmsanddrugelutingstentsdeserasfrom1984to2010 |