Drug-induced Liver Injury Associated with Mosapride Citrate: A Report of Two Cases

We herein report two cases of drug-induced liver injury (DILI) due to mosapride. Case 1: A 78-year-old man was admitted with elevated transaminase levels. The cessation of mosapride led to the improvement of elevated liver enzyme levels. Case 2: A 54-year-old man was admitted with jaundice. Mosaprid...

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Autores principales: Sako, Ayaka, Bae, Sung Kwan, Gushima, Toshifumi, Motoshita, Junichi, Bekki, Shigemune, Abiru, Seigo, Komori, Atsumasa, Shimoda, Shinji, Ito, Masahiro, Yatsuhashi, Hiroshi, Takahashi, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313423/
https://www.ncbi.nlm.nih.gov/pubmed/28049998
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author Sako, Ayaka
Bae, Sung Kwan
Gushima, Toshifumi
Motoshita, Junichi
Bekki, Shigemune
Abiru, Seigo
Komori, Atsumasa
Shimoda, Shinji
Ito, Masahiro
Yatsuhashi, Hiroshi
Takahashi, Kazuhiro
author_facet Sako, Ayaka
Bae, Sung Kwan
Gushima, Toshifumi
Motoshita, Junichi
Bekki, Shigemune
Abiru, Seigo
Komori, Atsumasa
Shimoda, Shinji
Ito, Masahiro
Yatsuhashi, Hiroshi
Takahashi, Kazuhiro
author_sort Sako, Ayaka
collection PubMed
description We herein report two cases of drug-induced liver injury (DILI) due to mosapride. Case 1: A 78-year-old man was admitted with elevated transaminase levels. The cessation of mosapride led to the improvement of elevated liver enzyme levels. Case 2: A 54-year-old man was admitted with jaundice. Mosapride was discontinued immediately, and methylprednisolone was administered for acute liver failure. The patient's data showed improvement, and he was discharged on Day 32. In both cases, mosapride gave a positive response to a drug-induced lymphocyte stimulation test (DLST), and the patient's score based on the criteria for DILI was “highly probable”.
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spelling pubmed-53134232017-02-28 Drug-induced Liver Injury Associated with Mosapride Citrate: A Report of Two Cases Sako, Ayaka Bae, Sung Kwan Gushima, Toshifumi Motoshita, Junichi Bekki, Shigemune Abiru, Seigo Komori, Atsumasa Shimoda, Shinji Ito, Masahiro Yatsuhashi, Hiroshi Takahashi, Kazuhiro Intern Med Case Report We herein report two cases of drug-induced liver injury (DILI) due to mosapride. Case 1: A 78-year-old man was admitted with elevated transaminase levels. The cessation of mosapride led to the improvement of elevated liver enzyme levels. Case 2: A 54-year-old man was admitted with jaundice. Mosapride was discontinued immediately, and methylprednisolone was administered for acute liver failure. The patient's data showed improvement, and he was discharged on Day 32. In both cases, mosapride gave a positive response to a drug-induced lymphocyte stimulation test (DLST), and the patient's score based on the criteria for DILI was “highly probable”. The Japanese Society of Internal Medicine 2017-01-01 /pmc/articles/PMC5313423/ /pubmed/28049998 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sako, Ayaka
Bae, Sung Kwan
Gushima, Toshifumi
Motoshita, Junichi
Bekki, Shigemune
Abiru, Seigo
Komori, Atsumasa
Shimoda, Shinji
Ito, Masahiro
Yatsuhashi, Hiroshi
Takahashi, Kazuhiro
Drug-induced Liver Injury Associated with Mosapride Citrate: A Report of Two Cases
title Drug-induced Liver Injury Associated with Mosapride Citrate: A Report of Two Cases
title_full Drug-induced Liver Injury Associated with Mosapride Citrate: A Report of Two Cases
title_fullStr Drug-induced Liver Injury Associated with Mosapride Citrate: A Report of Two Cases
title_full_unstemmed Drug-induced Liver Injury Associated with Mosapride Citrate: A Report of Two Cases
title_short Drug-induced Liver Injury Associated with Mosapride Citrate: A Report of Two Cases
title_sort drug-induced liver injury associated with mosapride citrate: a report of two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313423/
https://www.ncbi.nlm.nih.gov/pubmed/28049998
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