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Light Chain Deposition Disease Diagnosed with Laser Micro-dissection, Liquid Chromatography, and Tandem Mass Spectrometry of Nodular Glomerular Lesions
A 42-year-old man developed nephrotic syndrome and rapidly progressive renal failure. Kidney biopsy demonstrated nodular glomerulosclerosis, negative Congo red staining, and no deposition of light or heavy chains. Laser micro-dissection and liquid chromatography with tandem mass spectrometry of nodu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313426/ https://www.ncbi.nlm.nih.gov/pubmed/28050001 |
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author | Kasagi, Tomomichi Nobata, Hironobu Suzuki, Keisuke Miura, Naoto Banno, Shogo Takami, Akiyoshi Yamashita, Taro Ando, Yukio Imai, Hirokazu |
author_facet | Kasagi, Tomomichi Nobata, Hironobu Suzuki, Keisuke Miura, Naoto Banno, Shogo Takami, Akiyoshi Yamashita, Taro Ando, Yukio Imai, Hirokazu |
author_sort | Kasagi, Tomomichi |
collection | PubMed |
description | A 42-year-old man developed nephrotic syndrome and rapidly progressive renal failure. Kidney biopsy demonstrated nodular glomerulosclerosis, negative Congo red staining, and no deposition of light or heavy chains. Laser micro-dissection and liquid chromatography with tandem mass spectrometry of nodular lesions revealed the presence of a kappa chain constant region and kappa III variable region, which signified light chain deposition disease. Dexamethasone and thalidomide were effective in decreasing the serum levels of free kappa light chain from 147.0 to 38.0 mg/L, eliminating proteinuria, and halting the worsening of the kidney dysfunction, with serum creatinine levels stable around 4.0 mg/dL for 3 years. |
format | Online Article Text |
id | pubmed-5313426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-53134262017-02-28 Light Chain Deposition Disease Diagnosed with Laser Micro-dissection, Liquid Chromatography, and Tandem Mass Spectrometry of Nodular Glomerular Lesions Kasagi, Tomomichi Nobata, Hironobu Suzuki, Keisuke Miura, Naoto Banno, Shogo Takami, Akiyoshi Yamashita, Taro Ando, Yukio Imai, Hirokazu Intern Med Case Report A 42-year-old man developed nephrotic syndrome and rapidly progressive renal failure. Kidney biopsy demonstrated nodular glomerulosclerosis, negative Congo red staining, and no deposition of light or heavy chains. Laser micro-dissection and liquid chromatography with tandem mass spectrometry of nodular lesions revealed the presence of a kappa chain constant region and kappa III variable region, which signified light chain deposition disease. Dexamethasone and thalidomide were effective in decreasing the serum levels of free kappa light chain from 147.0 to 38.0 mg/L, eliminating proteinuria, and halting the worsening of the kidney dysfunction, with serum creatinine levels stable around 4.0 mg/dL for 3 years. The Japanese Society of Internal Medicine 2017-01-01 /pmc/articles/PMC5313426/ /pubmed/28050001 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Kasagi, Tomomichi Nobata, Hironobu Suzuki, Keisuke Miura, Naoto Banno, Shogo Takami, Akiyoshi Yamashita, Taro Ando, Yukio Imai, Hirokazu Light Chain Deposition Disease Diagnosed with Laser Micro-dissection, Liquid Chromatography, and Tandem Mass Spectrometry of Nodular Glomerular Lesions |
title | Light Chain Deposition Disease Diagnosed with Laser Micro-dissection, Liquid Chromatography, and Tandem Mass Spectrometry of Nodular Glomerular Lesions |
title_full | Light Chain Deposition Disease Diagnosed with Laser Micro-dissection, Liquid Chromatography, and Tandem Mass Spectrometry of Nodular Glomerular Lesions |
title_fullStr | Light Chain Deposition Disease Diagnosed with Laser Micro-dissection, Liquid Chromatography, and Tandem Mass Spectrometry of Nodular Glomerular Lesions |
title_full_unstemmed | Light Chain Deposition Disease Diagnosed with Laser Micro-dissection, Liquid Chromatography, and Tandem Mass Spectrometry of Nodular Glomerular Lesions |
title_short | Light Chain Deposition Disease Diagnosed with Laser Micro-dissection, Liquid Chromatography, and Tandem Mass Spectrometry of Nodular Glomerular Lesions |
title_sort | light chain deposition disease diagnosed with laser micro-dissection, liquid chromatography, and tandem mass spectrometry of nodular glomerular lesions |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313426/ https://www.ncbi.nlm.nih.gov/pubmed/28050001 |
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