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Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity

The human MutT homolog 1 (hMTH1, human NUDT1) hydrolyzes oxidatively damaged nucleoside triphosphates and is the main enzyme responsible for nucleotide sanitization. hMTH1 recently has received attention as an anticancer target because hMTH1 blockade leads to accumulation of oxidized nucleotides in...

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Detalles Bibliográficos
Autores principales:	Waz, Shaimaa, Nakamura, Teruya, Hirata, Keisuke, Koga-Ogawa, Yukari, Chirifu, Mami, Arimori, Takao, Tamada, Taro, Ikemizu, Shinji, Nakabeppu, Yusaku, Yamagata, Yuriko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314174/ https://www.ncbi.nlm.nih.gov/pubmed/28035004 http://dx.doi.org/10.1074/jbc.M116.749713

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