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Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity

The survival kinase Akt has clinical relevance to radioresistance. However, its contributions to the DNA damage response, DNA double strand break (DSB) repair and apoptosis remain poorly defined and often contradictory. We used a genetic approach to explore the consequences of genetic alterations of...

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Detalles Bibliográficos
Autores principales:	Oeck, S., Al-Refae, K., Riffkin, H., Wiel, G., Handrick, R., Klein, D., Iliakis, G., Jendrossek, V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314324/ https://www.ncbi.nlm.nih.gov/pubmed/28209968 http://dx.doi.org/10.1038/srep42700

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