Antisense miR-132 blockade via the AChE-R splice variant mitigates cortical inflammation

MicroRNA (miR)-132 brain-to-body messages suppress inflammation by targeting acetylcholinesterase (AChE), but the target specificity of 3’-AChE splice variants and the signaling pathways involved remain unknown. Using surface plasmon resonance (SPR), we identified preferential miR-132 targeting of s...

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Detalles Bibliográficos
Autores principales: Mishra, Nibha, Friedson, Lyndon, Hanin, Geula, Bekenstein, Uriya, Volovich, Meshi, Bennett, Estelle R., Greenberg, David S., Soreq, Hermona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314396/
https://www.ncbi.nlm.nih.gov/pubmed/28209997
http://dx.doi.org/10.1038/srep42755

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