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Integrated strategy for in vitro characterization of a bileaflet mechanical aortic valve
BACKGROUND: Haemodynamic performance of heart valve prosthesis can be defined as its ability to fully open and completely close during the cardiac cycle, neither overloading heart work nor damaging blood particles when passing through the valve. In this perspective, global and local flow parameters,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314609/ https://www.ncbi.nlm.nih.gov/pubmed/28209171 http://dx.doi.org/10.1186/s12938-017-0314-2 |
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author | Susin, Francesca Maria Espa, Stefania Toninato, Riccardo Fortini, Stefania Querzoli, Giorgio |
author_facet | Susin, Francesca Maria Espa, Stefania Toninato, Riccardo Fortini, Stefania Querzoli, Giorgio |
author_sort | Susin, Francesca Maria |
collection | PubMed |
description | BACKGROUND: Haemodynamic performance of heart valve prosthesis can be defined as its ability to fully open and completely close during the cardiac cycle, neither overloading heart work nor damaging blood particles when passing through the valve. In this perspective, global and local flow parameters, valve dynamics and blood damage safety of the prosthesis, as well as their mutual interactions, have all to be accounted for when assessing the device functionality. Even though all these issues have been and continue to be widely investigated, they are not usually studied through an integrated approach yet, i.e. by analyzing them simultaneously and highlighting their connections. RESULTS: An in vitro test campaign of flow through a bileaflet mechanical heart valve (Sorin Slimline 25 mm) was performed in a suitably arranged pulsatile mock loop able to reproduce human systemic pressure and flow curves. The valve was placed in an elastic, transparent, and anatomically accurate model of healthy aorta, and tested under several pulsatile flow conditions. Global and local hydrodynamics measurements and leaflet dynamics were analysed focusing on correlations between flow characteristics and valve motion. The haemolysis index due to the valve was estimated according to a literature power law model and related to hydrodynamic conditions, and a correlation between the spatial distribution of experimental shear stress and pannus/thrombotic deposits on mechanical valves was suggested. As main and general result, this study validates the potential of the integrated strategy for performance assessment of any prosthetic valve thanks to its capability of highlighting the complex interaction between the different physical mechanisms that govern transvalvular haemodynamics. CONCLUSIONS: We have defined an in vitro procedure for a comprehensive analysis of aortic valve prosthesis performance; the rationale for this study was the belief that a proper and overall characterization of the device should be based on the simultaneous measurement of all different quantities of interest for haemodynamic performance and the analysis of their mutual interactions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12938-017-0314-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5314609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53146092017-02-24 Integrated strategy for in vitro characterization of a bileaflet mechanical aortic valve Susin, Francesca Maria Espa, Stefania Toninato, Riccardo Fortini, Stefania Querzoli, Giorgio Biomed Eng Online Research BACKGROUND: Haemodynamic performance of heart valve prosthesis can be defined as its ability to fully open and completely close during the cardiac cycle, neither overloading heart work nor damaging blood particles when passing through the valve. In this perspective, global and local flow parameters, valve dynamics and blood damage safety of the prosthesis, as well as their mutual interactions, have all to be accounted for when assessing the device functionality. Even though all these issues have been and continue to be widely investigated, they are not usually studied through an integrated approach yet, i.e. by analyzing them simultaneously and highlighting their connections. RESULTS: An in vitro test campaign of flow through a bileaflet mechanical heart valve (Sorin Slimline 25 mm) was performed in a suitably arranged pulsatile mock loop able to reproduce human systemic pressure and flow curves. The valve was placed in an elastic, transparent, and anatomically accurate model of healthy aorta, and tested under several pulsatile flow conditions. Global and local hydrodynamics measurements and leaflet dynamics were analysed focusing on correlations between flow characteristics and valve motion. The haemolysis index due to the valve was estimated according to a literature power law model and related to hydrodynamic conditions, and a correlation between the spatial distribution of experimental shear stress and pannus/thrombotic deposits on mechanical valves was suggested. As main and general result, this study validates the potential of the integrated strategy for performance assessment of any prosthetic valve thanks to its capability of highlighting the complex interaction between the different physical mechanisms that govern transvalvular haemodynamics. CONCLUSIONS: We have defined an in vitro procedure for a comprehensive analysis of aortic valve prosthesis performance; the rationale for this study was the belief that a proper and overall characterization of the device should be based on the simultaneous measurement of all different quantities of interest for haemodynamic performance and the analysis of their mutual interactions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12938-017-0314-2) contains supplementary material, which is available to authorized users. BioMed Central 2017-02-16 /pmc/articles/PMC5314609/ /pubmed/28209171 http://dx.doi.org/10.1186/s12938-017-0314-2 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Susin, Francesca Maria Espa, Stefania Toninato, Riccardo Fortini, Stefania Querzoli, Giorgio Integrated strategy for in vitro characterization of a bileaflet mechanical aortic valve |
title | Integrated strategy for in vitro characterization of a bileaflet mechanical aortic valve |
title_full | Integrated strategy for in vitro characterization of a bileaflet mechanical aortic valve |
title_fullStr | Integrated strategy for in vitro characterization of a bileaflet mechanical aortic valve |
title_full_unstemmed | Integrated strategy for in vitro characterization of a bileaflet mechanical aortic valve |
title_short | Integrated strategy for in vitro characterization of a bileaflet mechanical aortic valve |
title_sort | integrated strategy for in vitro characterization of a bileaflet mechanical aortic valve |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314609/ https://www.ncbi.nlm.nih.gov/pubmed/28209171 http://dx.doi.org/10.1186/s12938-017-0314-2 |
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