Mouse genomic screen reveals novel host regulator of metastasis

Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune...

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Detalles Bibliográficos
Autores principales: Celià-Terrassa, Toni, Kang, Yibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314612/
https://www.ncbi.nlm.nih.gov/pubmed/28209174
http://dx.doi.org/10.1186/s13059-017-1170-x
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author Celià-Terrassa, Toni
Kang, Yibin
author_facet Celià-Terrassa, Toni
Kang, Yibin
author_sort Celià-Terrassa, Toni
collection PubMed
description Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune-mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastatic colonization.
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spelling pubmed-53146122017-02-24 Mouse genomic screen reveals novel host regulator of metastasis Celià-Terrassa, Toni Kang, Yibin Genome Biol Research Highlight Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune-mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastatic colonization. BioMed Central 2017-02-16 /pmc/articles/PMC5314612/ /pubmed/28209174 http://dx.doi.org/10.1186/s13059-017-1170-x Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Celià-Terrassa, Toni
Kang, Yibin
Mouse genomic screen reveals novel host regulator of metastasis
title Mouse genomic screen reveals novel host regulator of metastasis
title_full Mouse genomic screen reveals novel host regulator of metastasis
title_fullStr Mouse genomic screen reveals novel host regulator of metastasis
title_full_unstemmed Mouse genomic screen reveals novel host regulator of metastasis
title_short Mouse genomic screen reveals novel host regulator of metastasis
title_sort mouse genomic screen reveals novel host regulator of metastasis
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314612/
https://www.ncbi.nlm.nih.gov/pubmed/28209174
http://dx.doi.org/10.1186/s13059-017-1170-x
work_keys_str_mv AT celiaterrassatoni mousegenomicscreenrevealsnovelhostregulatorofmetastasis
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