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Penicillin production in industrial strain Penicillium chrysogenum P2niaD18 is not dependent on the copy number of biosynthesis genes

BACKGROUND: Multi-copy gene integration into microbial genomes is a conventional tool for obtaining improved gene expression. For Penicillium chrysogenum, the fungal producer of the beta-lactam antibiotic penicillin, many production strains carry multiple copies of the penicillin biosynthesis gene c...

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Detalles Bibliográficos
Autores principales:	Ziemons, Sandra, Koutsantas, Katerina, Becker, Kordula, Dahlmann, Tim, Kück, Ulrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314624/ https://www.ncbi.nlm.nih.gov/pubmed/28209150 http://dx.doi.org/10.1186/s12896-017-0335-8

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