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Increased Cortisol and Cortisone Levels in Overweight Children

BACKGROUND: It has been unclear whether relatively high cortisol and cortisone levels are related to overweight in childhood, parental body mass index (BMI), and family dietary habits. The aim of this study was to compare cortisol and cortisone levels in urine and saliva from overweight and normal c...

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Autores principales: Chu, Lanling, Sheng, Kangwei, Liu, Ping, Ye, Kan, Wang, Yu, Li, Chen, Kang, Xuejun, Song, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314734/
https://www.ncbi.nlm.nih.gov/pubmed/28179618
http://dx.doi.org/10.12659/MSMBR.902707
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author Chu, Lanling
Sheng, Kangwei
Liu, Ping
Ye, Kan
Wang, Yu
Li, Chen
Kang, Xuejun
Song, Yuan
author_facet Chu, Lanling
Sheng, Kangwei
Liu, Ping
Ye, Kan
Wang, Yu
Li, Chen
Kang, Xuejun
Song, Yuan
author_sort Chu, Lanling
collection PubMed
description BACKGROUND: It has been unclear whether relatively high cortisol and cortisone levels are related to overweight in childhood, parental body mass index (BMI), and family dietary habits. The aim of this study was to compare cortisol and cortisone levels in urine and saliva from overweight and normal children, as well as correlations between children’s BMI, parental BMI and family dietary behavior questionnaire score (QS). MATERIAL/METHODS: We analyzed the data from 52 overweight children and 53 age- and sex-matched normal-weight children aged 4–5 years. The concentrations of salivary cortisol (SF), salivary cortisone (SE), urinary cortisol (UF) and urinary cortisone (UE) were measured using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The family dietary behavior QS was answered by the parent mainly responsible for the family diet. RESULTS: Average cortisol and cortisone levels were significantly higher in overweight children. There was no significant difference in the ratio of cortisol to cortisone (R(cc)) and the marker of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) activities. The results displayed correlations among cortisol, cortisone, and R(cc). Positive correlations were weak-to-moderate between BMI and SF, SE, UF, and UE. There were correlations between BMI and maternal BMI (mBMI), and BMI was significantly associated with QS. CONCLUSIONS: Our results suggest that cortisol and cortisone levels are associated with overweight in children, but the 11β-HSD2 activities showed no significant differences. Unhealthy family diet was associated with higher BMI, UF, and UE, and families with maternal overweight or obesity had a higher prevalence of children’s overweight or obesity.
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spelling pubmed-53147342017-03-01 Increased Cortisol and Cortisone Levels in Overweight Children Chu, Lanling Sheng, Kangwei Liu, Ping Ye, Kan Wang, Yu Li, Chen Kang, Xuejun Song, Yuan Med Sci Monit Basic Res Human Study BACKGROUND: It has been unclear whether relatively high cortisol and cortisone levels are related to overweight in childhood, parental body mass index (BMI), and family dietary habits. The aim of this study was to compare cortisol and cortisone levels in urine and saliva from overweight and normal children, as well as correlations between children’s BMI, parental BMI and family dietary behavior questionnaire score (QS). MATERIAL/METHODS: We analyzed the data from 52 overweight children and 53 age- and sex-matched normal-weight children aged 4–5 years. The concentrations of salivary cortisol (SF), salivary cortisone (SE), urinary cortisol (UF) and urinary cortisone (UE) were measured using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The family dietary behavior QS was answered by the parent mainly responsible for the family diet. RESULTS: Average cortisol and cortisone levels were significantly higher in overweight children. There was no significant difference in the ratio of cortisol to cortisone (R(cc)) and the marker of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) activities. The results displayed correlations among cortisol, cortisone, and R(cc). Positive correlations were weak-to-moderate between BMI and SF, SE, UF, and UE. There were correlations between BMI and maternal BMI (mBMI), and BMI was significantly associated with QS. CONCLUSIONS: Our results suggest that cortisol and cortisone levels are associated with overweight in children, but the 11β-HSD2 activities showed no significant differences. Unhealthy family diet was associated with higher BMI, UF, and UE, and families with maternal overweight or obesity had a higher prevalence of children’s overweight or obesity. International Scientific Literature, Inc. 2017-02-09 /pmc/articles/PMC5314734/ /pubmed/28179618 http://dx.doi.org/10.12659/MSMBR.902707 Text en © Med Sci Monit, 2017 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
spellingShingle Human Study
Chu, Lanling
Sheng, Kangwei
Liu, Ping
Ye, Kan
Wang, Yu
Li, Chen
Kang, Xuejun
Song, Yuan
Increased Cortisol and Cortisone Levels in Overweight Children
title Increased Cortisol and Cortisone Levels in Overweight Children
title_full Increased Cortisol and Cortisone Levels in Overweight Children
title_fullStr Increased Cortisol and Cortisone Levels in Overweight Children
title_full_unstemmed Increased Cortisol and Cortisone Levels in Overweight Children
title_short Increased Cortisol and Cortisone Levels in Overweight Children
title_sort increased cortisol and cortisone levels in overweight children
topic Human Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314734/
https://www.ncbi.nlm.nih.gov/pubmed/28179618
http://dx.doi.org/10.12659/MSMBR.902707
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