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C (3)-symmetric opioid scaffolds are pH-responsive DNA condensation agents

Herein we report the synthesis of tripodal C(3)-symmetric opioid scaffolds as high-affinity condensation agents of duplex DNA. Condensation was achieved on both supercoiled and canonical B-DNA structures and identified by agarose electrophoresis, viscosity, turbidity and atomic force microscopy (AFM...

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Detalles Bibliográficos
Autores principales:	McStay, Natasha, Molphy, Zara, Coughlan, Alan, Cafolla, Attilio, McKee, Vickie, Gathergood, Nicholas, Kellett, Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314759/ https://www.ncbi.nlm.nih.gov/pubmed/27899572 http://dx.doi.org/10.1093/nar/gkw1097

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