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Intron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation
The first intronic mutations in the intron 1 GATA site (int-1-GATA) of 5-aminolevulinate synthase 2 (ALAS2) have been identified in X-linked sideroblastic anemia (XLSA) pedigrees, strongly suggesting it could be causal mutations of XLSA. However, the function of this int-1-GATA site during in vivo d...
Autores principales: | Zhang, Yingchi, Zhang, Jingliao, An, Wenbin, Wan, Yang, Ma, Shihui, Yin, Jie, Li, Xichuan, Gao, Jie, Yuan, Weiping, Guo, Ye, Engel, James Douglas, Shi, Lihong, Cheng, Tao, Zhu, Xiaofan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314798/ https://www.ncbi.nlm.nih.gov/pubmed/28123038 http://dx.doi.org/10.1093/nar/gkw901 |
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