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Intron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation

The first intronic mutations in the intron 1 GATA site (int-1-GATA) of 5-aminolevulinate synthase 2 (ALAS2) have been identified in X-linked sideroblastic anemia (XLSA) pedigrees, strongly suggesting it could be causal mutations of XLSA. However, the function of this int-1-GATA site during in vivo d...

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Detalles Bibliográficos
Autores principales:	Zhang, Yingchi, Zhang, Jingliao, An, Wenbin, Wan, Yang, Ma, Shihui, Yin, Jie, Li, Xichuan, Gao, Jie, Yuan, Weiping, Guo, Ye, Engel, James Douglas, Shi, Lihong, Cheng, Tao, Zhu, Xiaofan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314798/ https://www.ncbi.nlm.nih.gov/pubmed/28123038 http://dx.doi.org/10.1093/nar/gkw901

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