Liquid Chromatography–Mass Spectrometry/Mass Spectrometry Analysis and Pharmacokinetic Assessment of Ponatinib in Sprague–Dawley Rats

INTRODUCTION: By means of liquid–liquid extraction with ethyl acetate, a rapid, sensitive, and specific LC–MS/MS method was developed and validated for assaying ponatinib and the internal standard, warfarin. METHODS: The method was verified and successfully applied to evaluate the pharmacokinetics o...

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Detalles Bibliográficos
Autores principales: Wang, Pei, Peng, Ying, Zhang, Xiaolan, Fei, Fei, Wang, Shuyao, Feng, Siqi, Huang, Jingqiu, Wang, Hongbo, Aa, Jiye, Wang, Guangji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315062/
https://www.ncbi.nlm.nih.gov/pubmed/28261644
http://dx.doi.org/10.1007/s40487-016-0022-2

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