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Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals

Liquid crystal (LC) dosage forms, particularly those using lipid-based lyotropic LCs (LLCs), have generated considerable interest as potential drug delivery systems. LCs have the physical properties of liquids but retain some of the structural characteristics of crystalline solids. They are compatib...

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Autores principales: Rajabalaya, Rajan, Musa, Muhammad Nuh, Kifli, Nurolaini, David, Sheba R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315216/
https://www.ncbi.nlm.nih.gov/pubmed/28243062
http://dx.doi.org/10.2147/DDDT.S103505
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author Rajabalaya, Rajan
Musa, Muhammad Nuh
Kifli, Nurolaini
David, Sheba R
author_facet Rajabalaya, Rajan
Musa, Muhammad Nuh
Kifli, Nurolaini
David, Sheba R
author_sort Rajabalaya, Rajan
collection PubMed
description Liquid crystal (LC) dosage forms, particularly those using lipid-based lyotropic LCs (LLCs), have generated considerable interest as potential drug delivery systems. LCs have the physical properties of liquids but retain some of the structural characteristics of crystalline solids. They are compatible with hydrophobic and hydrophilic compounds of many different classes and can protect even biologicals and nucleic acids from degradation. This review, focused on research conducted over the past 5 years, discusses the structural evaluation of LCs and their effects in drug formulations. The structural classification of LLCs into lamellar, hexagonal and micellar cubic phases is described. The structures of these phases are influenced by the addition of surfactants, which include a variety of nontoxic, biodegradable lipids; these also enhance drug solubility. LLC structure influences drug localization, particle size and viscosity, which, in turn, determine drug delivery properties. Through several specific examples, we describe the applications of LLCs in oral and topical drug formulations, the latter including transdermal and ocular delivery. In oral LLC formulations, micelle compositions and the resulting LLC structures can determine drug solubilization and stability as well as intestinal transport and absorption. Similarly, in topical LLC formulations, composition can influence whether the drug is retained in the skin or delivered transdermally. Owing to their enhancement of drug stability and promotion of controlled drug delivery, LLCs are becoming increasingly popular in pharmaceutical formulations.
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spelling pubmed-53152162017-02-27 Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals Rajabalaya, Rajan Musa, Muhammad Nuh Kifli, Nurolaini David, Sheba R Drug Des Devel Ther Review Liquid crystal (LC) dosage forms, particularly those using lipid-based lyotropic LCs (LLCs), have generated considerable interest as potential drug delivery systems. LCs have the physical properties of liquids but retain some of the structural characteristics of crystalline solids. They are compatible with hydrophobic and hydrophilic compounds of many different classes and can protect even biologicals and nucleic acids from degradation. This review, focused on research conducted over the past 5 years, discusses the structural evaluation of LCs and their effects in drug formulations. The structural classification of LLCs into lamellar, hexagonal and micellar cubic phases is described. The structures of these phases are influenced by the addition of surfactants, which include a variety of nontoxic, biodegradable lipids; these also enhance drug solubility. LLC structure influences drug localization, particle size and viscosity, which, in turn, determine drug delivery properties. Through several specific examples, we describe the applications of LLCs in oral and topical drug formulations, the latter including transdermal and ocular delivery. In oral LLC formulations, micelle compositions and the resulting LLC structures can determine drug solubilization and stability as well as intestinal transport and absorption. Similarly, in topical LLC formulations, composition can influence whether the drug is retained in the skin or delivered transdermally. Owing to their enhancement of drug stability and promotion of controlled drug delivery, LLCs are becoming increasingly popular in pharmaceutical formulations. Dove Medical Press 2017-02-13 /pmc/articles/PMC5315216/ /pubmed/28243062 http://dx.doi.org/10.2147/DDDT.S103505 Text en © 2017 Rajabalaya et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Rajabalaya, Rajan
Musa, Muhammad Nuh
Kifli, Nurolaini
David, Sheba R
Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals
title Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals
title_full Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals
title_fullStr Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals
title_full_unstemmed Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals
title_short Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals
title_sort oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315216/
https://www.ncbi.nlm.nih.gov/pubmed/28243062
http://dx.doi.org/10.2147/DDDT.S103505
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