Cargando…

Prevalence and associated comorbidities of restless legs syndrome (RLS): Data from a large population-based door-to-door survey on 19176 adults in Tehran, Iran

BACKGROUND: Discrepancies have been reported in the prevalence rate of restless legs syndrome (RLS) among different ethnic groups and geographic populations. Furthermore, there are disagreements on determinant factors and associated comorbidities of RLS. We aimed to estimate prevalence of RLS and in...

Descripción completa

Detalles Bibliográficos
Autores principales: Fereshtehnejad, Seyed-Mohammad, Rahmani, Arash, Shafieesabet, Mahdiyeh, Soori, Mahshid, Delbari, Ahmad, Motamed, Mohammad Reza, Lökk, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315310/
https://www.ncbi.nlm.nih.gov/pubmed/28212408
http://dx.doi.org/10.1371/journal.pone.0172593
_version_ 1782508669701718016
author Fereshtehnejad, Seyed-Mohammad
Rahmani, Arash
Shafieesabet, Mahdiyeh
Soori, Mahshid
Delbari, Ahmad
Motamed, Mohammad Reza
Lökk, Johan
author_facet Fereshtehnejad, Seyed-Mohammad
Rahmani, Arash
Shafieesabet, Mahdiyeh
Soori, Mahshid
Delbari, Ahmad
Motamed, Mohammad Reza
Lökk, Johan
author_sort Fereshtehnejad, Seyed-Mohammad
collection PubMed
description BACKGROUND: Discrepancies have been reported in the prevalence rate of restless legs syndrome (RLS) among different ethnic groups and geographic populations. Furthermore, there are disagreements on determinant factors and associated comorbidities of RLS. We aimed to estimate prevalence of RLS and investigate its associated comorbid conditions and risk factors in a large population-based door-to-door survey. METHODS: Following a multistage random sampling from the households lived in 22 urban districts of Tehran, Iran, 19176 participants with ≥30 years of age were recruited. Trained surveyors filled study checklist consisting of baseline characteristics, risk factors and comorbidity profile and the International RLS Study Group (IRLSSG) diagnostic criteria through face-to-face interviews. RESULTS: In total, 1580 individuals were positively screened for RLS resulting in a standardized prevalence rate of 60.0/1000. There was a gradual increase in RLS prevalence by advancing age, however, sex difference disappeared after adjustment. Parkinsonism [adjusted odds’ ratio (adj-OR) = 7.4 (95% CI: 5.3–10.4)], peripheral neuropathy [adj-OR = 3.7 (95% CI: 3.3–4.1)], subjective cognitive impairment (SCI) [adj-OR = 3.1 (95% CI: 2.7–3.4)], acting out dreams [adj-OR = 2.8 (95% CI: 2.5–3.2)], hyposmia [adj-OR = 2.5 (95% CI: 2.2–2.9)], active smoking [adj-OR = 1.5 (95% CI: 1.3–1.9)] and additional number of cardiometabolic diseases associated with higher risk of RLS [adj-OR = 1.6 (95% CI: 1.2–2.3)]. CONCLUSION: Our findings showed that neuro-cognitive co-morbidities such as parkinsonism, peripheral neuropathy, SCI, acting out dreams and hyposmia as well as cardio-metabolic risk factors and diseases were independent determinants of RLS. It is recommended to screen individuals with either these comorbid conditions for RLS or the ones with RLS for the accompanying diseases.
format Online
Article
Text
id pubmed-5315310
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-53153102017-03-03 Prevalence and associated comorbidities of restless legs syndrome (RLS): Data from a large population-based door-to-door survey on 19176 adults in Tehran, Iran Fereshtehnejad, Seyed-Mohammad Rahmani, Arash Shafieesabet, Mahdiyeh Soori, Mahshid Delbari, Ahmad Motamed, Mohammad Reza Lökk, Johan PLoS One Research Article BACKGROUND: Discrepancies have been reported in the prevalence rate of restless legs syndrome (RLS) among different ethnic groups and geographic populations. Furthermore, there are disagreements on determinant factors and associated comorbidities of RLS. We aimed to estimate prevalence of RLS and investigate its associated comorbid conditions and risk factors in a large population-based door-to-door survey. METHODS: Following a multistage random sampling from the households lived in 22 urban districts of Tehran, Iran, 19176 participants with ≥30 years of age were recruited. Trained surveyors filled study checklist consisting of baseline characteristics, risk factors and comorbidity profile and the International RLS Study Group (IRLSSG) diagnostic criteria through face-to-face interviews. RESULTS: In total, 1580 individuals were positively screened for RLS resulting in a standardized prevalence rate of 60.0/1000. There was a gradual increase in RLS prevalence by advancing age, however, sex difference disappeared after adjustment. Parkinsonism [adjusted odds’ ratio (adj-OR) = 7.4 (95% CI: 5.3–10.4)], peripheral neuropathy [adj-OR = 3.7 (95% CI: 3.3–4.1)], subjective cognitive impairment (SCI) [adj-OR = 3.1 (95% CI: 2.7–3.4)], acting out dreams [adj-OR = 2.8 (95% CI: 2.5–3.2)], hyposmia [adj-OR = 2.5 (95% CI: 2.2–2.9)], active smoking [adj-OR = 1.5 (95% CI: 1.3–1.9)] and additional number of cardiometabolic diseases associated with higher risk of RLS [adj-OR = 1.6 (95% CI: 1.2–2.3)]. CONCLUSION: Our findings showed that neuro-cognitive co-morbidities such as parkinsonism, peripheral neuropathy, SCI, acting out dreams and hyposmia as well as cardio-metabolic risk factors and diseases were independent determinants of RLS. It is recommended to screen individuals with either these comorbid conditions for RLS or the ones with RLS for the accompanying diseases. Public Library of Science 2017-02-17 /pmc/articles/PMC5315310/ /pubmed/28212408 http://dx.doi.org/10.1371/journal.pone.0172593 Text en © 2017 Fereshtehnejad et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Fereshtehnejad, Seyed-Mohammad
Rahmani, Arash
Shafieesabet, Mahdiyeh
Soori, Mahshid
Delbari, Ahmad
Motamed, Mohammad Reza
Lökk, Johan
Prevalence and associated comorbidities of restless legs syndrome (RLS): Data from a large population-based door-to-door survey on 19176 adults in Tehran, Iran
title Prevalence and associated comorbidities of restless legs syndrome (RLS): Data from a large population-based door-to-door survey on 19176 adults in Tehran, Iran
title_full Prevalence and associated comorbidities of restless legs syndrome (RLS): Data from a large population-based door-to-door survey on 19176 adults in Tehran, Iran
title_fullStr Prevalence and associated comorbidities of restless legs syndrome (RLS): Data from a large population-based door-to-door survey on 19176 adults in Tehran, Iran
title_full_unstemmed Prevalence and associated comorbidities of restless legs syndrome (RLS): Data from a large population-based door-to-door survey on 19176 adults in Tehran, Iran
title_short Prevalence and associated comorbidities of restless legs syndrome (RLS): Data from a large population-based door-to-door survey on 19176 adults in Tehran, Iran
title_sort prevalence and associated comorbidities of restless legs syndrome (rls): data from a large population-based door-to-door survey on 19176 adults in tehran, iran
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315310/
https://www.ncbi.nlm.nih.gov/pubmed/28212408
http://dx.doi.org/10.1371/journal.pone.0172593
work_keys_str_mv AT fereshtehnejadseyedmohammad prevalenceandassociatedcomorbiditiesofrestlesslegssyndromerlsdatafromalargepopulationbaseddoortodoorsurveyon19176adultsintehraniran
AT rahmaniarash prevalenceandassociatedcomorbiditiesofrestlesslegssyndromerlsdatafromalargepopulationbaseddoortodoorsurveyon19176adultsintehraniran
AT shafieesabetmahdiyeh prevalenceandassociatedcomorbiditiesofrestlesslegssyndromerlsdatafromalargepopulationbaseddoortodoorsurveyon19176adultsintehraniran
AT soorimahshid prevalenceandassociatedcomorbiditiesofrestlesslegssyndromerlsdatafromalargepopulationbaseddoortodoorsurveyon19176adultsintehraniran
AT delbariahmad prevalenceandassociatedcomorbiditiesofrestlesslegssyndromerlsdatafromalargepopulationbaseddoortodoorsurveyon19176adultsintehraniran
AT motamedmohammadreza prevalenceandassociatedcomorbiditiesofrestlesslegssyndromerlsdatafromalargepopulationbaseddoortodoorsurveyon19176adultsintehraniran
AT lokkjohan prevalenceandassociatedcomorbiditiesofrestlesslegssyndromerlsdatafromalargepopulationbaseddoortodoorsurveyon19176adultsintehraniran