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Development and preliminary validation of the focused analgesia selection test to identify accurate pain reporters
Clinical trials of analgesics have been plagued with poor assay sensitivity due, in part, to variability in subjects’ pain reporting. Herein, we develop and evaluate the focused analgesia selection test (FAST), a method to measure patients’ pain reporting skills. Subjects with osteoarthritis of the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315353/ https://www.ncbi.nlm.nih.gov/pubmed/28243138 http://dx.doi.org/10.2147/JPR.S121455 |
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author | Treister, Roi Eaton, Thomas A Trudeau, Jeremiah J Elder, Harrison Katz, Nathaniel P |
author_facet | Treister, Roi Eaton, Thomas A Trudeau, Jeremiah J Elder, Harrison Katz, Nathaniel P |
author_sort | Treister, Roi |
collection | PubMed |
description | Clinical trials of analgesics have been plagued with poor assay sensitivity due, in part, to variability in subjects’ pain reporting. Herein, we develop and evaluate the focused analgesia selection test (FAST), a method to measure patients’ pain reporting skills. Subjects with osteoarthritis of the hip, knee, and/or ankle with pain intensity of ≥3/10 on a 0–10 numerical rating scale were enrolled. Subjects underwent the FAST procedure, which consists of recording subjects’ pain reports in response to repeated administration of thermal noxious stimuli of various intensities applied on the arm with the Medoc(®) Thermal Sensory Analyzer II. Subjects also rated non-noxious stimuli consisting of visual contrast rating. After performing an exercise task, subjects also rated clinical pain and were asked to report whether their pain had increased, decreased, or stayed the same. Overall, 88 subjects were enrolled, and 83 were included in the analyses. FAST’s outcomes including the R(2), intraclass correlation coefficient (ICC), and coefficient of variation (CoV) indicated that subjects’ pain reporting skills were widely distributed. Higher FAST ICC significantly predicted greater changes in clinical pain following exercise (p=0.017), whereas the visual contrast test did not predict postexercise pain. FAST is the first method that measures subjects’ pain reporting skills. Using FAST to enrich clinical trials with “good” pain reporters (with high FAST ICC) could increase assay sensitivity. Further evaluation of FAST is ongoing. |
format | Online Article Text |
id | pubmed-5315353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-53153532017-02-27 Development and preliminary validation of the focused analgesia selection test to identify accurate pain reporters Treister, Roi Eaton, Thomas A Trudeau, Jeremiah J Elder, Harrison Katz, Nathaniel P J Pain Res Original Research Clinical trials of analgesics have been plagued with poor assay sensitivity due, in part, to variability in subjects’ pain reporting. Herein, we develop and evaluate the focused analgesia selection test (FAST), a method to measure patients’ pain reporting skills. Subjects with osteoarthritis of the hip, knee, and/or ankle with pain intensity of ≥3/10 on a 0–10 numerical rating scale were enrolled. Subjects underwent the FAST procedure, which consists of recording subjects’ pain reports in response to repeated administration of thermal noxious stimuli of various intensities applied on the arm with the Medoc(®) Thermal Sensory Analyzer II. Subjects also rated non-noxious stimuli consisting of visual contrast rating. After performing an exercise task, subjects also rated clinical pain and were asked to report whether their pain had increased, decreased, or stayed the same. Overall, 88 subjects were enrolled, and 83 were included in the analyses. FAST’s outcomes including the R(2), intraclass correlation coefficient (ICC), and coefficient of variation (CoV) indicated that subjects’ pain reporting skills were widely distributed. Higher FAST ICC significantly predicted greater changes in clinical pain following exercise (p=0.017), whereas the visual contrast test did not predict postexercise pain. FAST is the first method that measures subjects’ pain reporting skills. Using FAST to enrich clinical trials with “good” pain reporters (with high FAST ICC) could increase assay sensitivity. Further evaluation of FAST is ongoing. Dove Medical Press 2017-02-09 /pmc/articles/PMC5315353/ /pubmed/28243138 http://dx.doi.org/10.2147/JPR.S121455 Text en © 2017 Treister et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Treister, Roi Eaton, Thomas A Trudeau, Jeremiah J Elder, Harrison Katz, Nathaniel P Development and preliminary validation of the focused analgesia selection test to identify accurate pain reporters |
title | Development and preliminary validation of the focused analgesia selection test to identify accurate pain reporters |
title_full | Development and preliminary validation of the focused analgesia selection test to identify accurate pain reporters |
title_fullStr | Development and preliminary validation of the focused analgesia selection test to identify accurate pain reporters |
title_full_unstemmed | Development and preliminary validation of the focused analgesia selection test to identify accurate pain reporters |
title_short | Development and preliminary validation of the focused analgesia selection test to identify accurate pain reporters |
title_sort | development and preliminary validation of the focused analgesia selection test to identify accurate pain reporters |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315353/ https://www.ncbi.nlm.nih.gov/pubmed/28243138 http://dx.doi.org/10.2147/JPR.S121455 |
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