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Age-associated molecular changes are deleterious and may modulate life span through diet
Transition through life span is accompanied by numerous molecular changes, such as dysregulated gene expression, altered metabolite levels, and accumulated molecular damage. These changes are thought to be causal factors in aging; however, because they are numerous and are also influenced by genotyp...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315447/ https://www.ncbi.nlm.nih.gov/pubmed/28232953 http://dx.doi.org/10.1126/sciadv.1601833 |
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author | Lee, Sang-Goo Kaya, Alaattin Avanesov, Andrei S. Podolskiy, Dmitriy I. Song, Eun Ju Go, Du-Min Jin, Gwi-Deuk Hwang, Jae Yeon Kim, Eun Bae Kim, Dae-Yong Gladyshev, Vadim N. |
author_facet | Lee, Sang-Goo Kaya, Alaattin Avanesov, Andrei S. Podolskiy, Dmitriy I. Song, Eun Ju Go, Du-Min Jin, Gwi-Deuk Hwang, Jae Yeon Kim, Eun Bae Kim, Dae-Yong Gladyshev, Vadim N. |
author_sort | Lee, Sang-Goo |
collection | PubMed |
description | Transition through life span is accompanied by numerous molecular changes, such as dysregulated gene expression, altered metabolite levels, and accumulated molecular damage. These changes are thought to be causal factors in aging; however, because they are numerous and are also influenced by genotype, environment, and other factors in addition to age, it is difficult to characterize the cumulative effect of these molecular changes on longevity. We reasoned that age-associated changes, such as molecular damage and tissue composition, may influence life span when used in the diet of organisms that are closely related to those that serve as a dietary source. To test this possibility, we used species-specific culture media and diets that incorporated molecular extracts of young and old organisms and compared the influence of these diets on the life span of yeast, fruitflies, and mice. In each case, the “old” diet or medium shortened the life span for one or both sexes. These findings suggest that age-associated molecular changes, such as cumulative damage and altered dietary composition, are deleterious and causally linked with aging and may affect life span through diet. |
format | Online Article Text |
id | pubmed-5315447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-53154472017-02-23 Age-associated molecular changes are deleterious and may modulate life span through diet Lee, Sang-Goo Kaya, Alaattin Avanesov, Andrei S. Podolskiy, Dmitriy I. Song, Eun Ju Go, Du-Min Jin, Gwi-Deuk Hwang, Jae Yeon Kim, Eun Bae Kim, Dae-Yong Gladyshev, Vadim N. Sci Adv Research Articles Transition through life span is accompanied by numerous molecular changes, such as dysregulated gene expression, altered metabolite levels, and accumulated molecular damage. These changes are thought to be causal factors in aging; however, because they are numerous and are also influenced by genotype, environment, and other factors in addition to age, it is difficult to characterize the cumulative effect of these molecular changes on longevity. We reasoned that age-associated changes, such as molecular damage and tissue composition, may influence life span when used in the diet of organisms that are closely related to those that serve as a dietary source. To test this possibility, we used species-specific culture media and diets that incorporated molecular extracts of young and old organisms and compared the influence of these diets on the life span of yeast, fruitflies, and mice. In each case, the “old” diet or medium shortened the life span for one or both sexes. These findings suggest that age-associated molecular changes, such as cumulative damage and altered dietary composition, are deleterious and causally linked with aging and may affect life span through diet. American Association for the Advancement of Science 2017-02-17 /pmc/articles/PMC5315447/ /pubmed/28232953 http://dx.doi.org/10.1126/sciadv.1601833 Text en Copyright © 2017, The Authors http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Lee, Sang-Goo Kaya, Alaattin Avanesov, Andrei S. Podolskiy, Dmitriy I. Song, Eun Ju Go, Du-Min Jin, Gwi-Deuk Hwang, Jae Yeon Kim, Eun Bae Kim, Dae-Yong Gladyshev, Vadim N. Age-associated molecular changes are deleterious and may modulate life span through diet |
title | Age-associated molecular changes are deleterious and may modulate life span through diet |
title_full | Age-associated molecular changes are deleterious and may modulate life span through diet |
title_fullStr | Age-associated molecular changes are deleterious and may modulate life span through diet |
title_full_unstemmed | Age-associated molecular changes are deleterious and may modulate life span through diet |
title_short | Age-associated molecular changes are deleterious and may modulate life span through diet |
title_sort | age-associated molecular changes are deleterious and may modulate life span through diet |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315447/ https://www.ncbi.nlm.nih.gov/pubmed/28232953 http://dx.doi.org/10.1126/sciadv.1601833 |
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