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Codon optimization underpins generalist parasitism in fungi
The range of hosts that parasites can infect is a key determinant of the emergence and spread of disease. Yet, the impact of host range variation on the evolution of parasite genomes remains unknown. Here, we show that codon optimization underlies genome adaptation in broad host range parasites. We...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315462/ https://www.ncbi.nlm.nih.gov/pubmed/28157073 http://dx.doi.org/10.7554/eLife.22472 |
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author | Badet, Thomas Peyraud, Remi Mbengue, Malick Navaud, Olivier Derbyshire, Mark Oliver, Richard P Barbacci, Adelin Raffaele, Sylvain |
author_facet | Badet, Thomas Peyraud, Remi Mbengue, Malick Navaud, Olivier Derbyshire, Mark Oliver, Richard P Barbacci, Adelin Raffaele, Sylvain |
author_sort | Badet, Thomas |
collection | PubMed |
description | The range of hosts that parasites can infect is a key determinant of the emergence and spread of disease. Yet, the impact of host range variation on the evolution of parasite genomes remains unknown. Here, we show that codon optimization underlies genome adaptation in broad host range parasites. We found that the longer proteins encoded by broad host range fungi likely increase natural selection on codon optimization in these species. Accordingly, codon optimization correlates with host range across the fungal kingdom. At the species level, biased patterns of synonymous substitutions underpin increased codon optimization in a generalist but not a specialist fungal pathogen. Virulence genes were consistently enriched in highly codon-optimized genes of generalist but not specialist species. We conclude that codon optimization is related to the capacity of parasites to colonize multiple hosts. Our results link genome evolution and translational regulation to the long-term persistence of generalist parasitism. DOI: http://dx.doi.org/10.7554/eLife.22472.001 |
format | Online Article Text |
id | pubmed-5315462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-53154622017-02-21 Codon optimization underpins generalist parasitism in fungi Badet, Thomas Peyraud, Remi Mbengue, Malick Navaud, Olivier Derbyshire, Mark Oliver, Richard P Barbacci, Adelin Raffaele, Sylvain eLife Genomics and Evolutionary Biology The range of hosts that parasites can infect is a key determinant of the emergence and spread of disease. Yet, the impact of host range variation on the evolution of parasite genomes remains unknown. Here, we show that codon optimization underlies genome adaptation in broad host range parasites. We found that the longer proteins encoded by broad host range fungi likely increase natural selection on codon optimization in these species. Accordingly, codon optimization correlates with host range across the fungal kingdom. At the species level, biased patterns of synonymous substitutions underpin increased codon optimization in a generalist but not a specialist fungal pathogen. Virulence genes were consistently enriched in highly codon-optimized genes of generalist but not specialist species. We conclude that codon optimization is related to the capacity of parasites to colonize multiple hosts. Our results link genome evolution and translational regulation to the long-term persistence of generalist parasitism. DOI: http://dx.doi.org/10.7554/eLife.22472.001 eLife Sciences Publications, Ltd 2017-02-03 /pmc/articles/PMC5315462/ /pubmed/28157073 http://dx.doi.org/10.7554/eLife.22472 Text en © 2017, Badet et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Genomics and Evolutionary Biology Badet, Thomas Peyraud, Remi Mbengue, Malick Navaud, Olivier Derbyshire, Mark Oliver, Richard P Barbacci, Adelin Raffaele, Sylvain Codon optimization underpins generalist parasitism in fungi |
title | Codon optimization underpins generalist parasitism in fungi |
title_full | Codon optimization underpins generalist parasitism in fungi |
title_fullStr | Codon optimization underpins generalist parasitism in fungi |
title_full_unstemmed | Codon optimization underpins generalist parasitism in fungi |
title_short | Codon optimization underpins generalist parasitism in fungi |
title_sort | codon optimization underpins generalist parasitism in fungi |
topic | Genomics and Evolutionary Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315462/ https://www.ncbi.nlm.nih.gov/pubmed/28157073 http://dx.doi.org/10.7554/eLife.22472 |
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