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Modulation of motor inhibition by subthalamic stimulation in obsessive-compulsive disorder
High-frequency deep brain stimulation of the subthalamic nucleus can be used to treat severe obsessive-compulsive disorders that are refractory to conventional treatments. The mechanisms of action of this approach possibly rely on the modulation of associative-limbic subcortical–cortical loops, but...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315551/ https://www.ncbi.nlm.nih.gov/pubmed/27754484 http://dx.doi.org/10.1038/tp.2016.192 |
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author | Kibleur, A Gras-Combe, G Benis, D Bastin, J Bougerol, T Chabardès, S Polosan, M David, O |
author_facet | Kibleur, A Gras-Combe, G Benis, D Bastin, J Bougerol, T Chabardès, S Polosan, M David, O |
author_sort | Kibleur, A |
collection | PubMed |
description | High-frequency deep brain stimulation of the subthalamic nucleus can be used to treat severe obsessive-compulsive disorders that are refractory to conventional treatments. The mechanisms of action of this approach possibly rely on the modulation of associative-limbic subcortical–cortical loops, but remain to be fully elucidated. Here in 12 patients, we report the effects of high-frequency stimulation of the subthalamic nucleus on behavior, and on electroencephalographic responses and inferred effective connectivity during motor inhibition processes involved in the stop signal task. First, we found that patients were faster to respond and had slower motor inhibition processes when stimulated. Second, the subthalamic stimulation modulated the amplitude and delayed inhibition-related electroencephalographic responses. The power of reconstructed cortical current densities decreased in the stimulation condition in a parietal–frontal network including cortical regions of the inhibition network such as the superior parts of the inferior frontal gyri and the dorsolateral prefrontal cortex. Finally, dynamic causal modeling revealed that the subthalamic stimulation was more likely to modulate efferent connections from the basal ganglia, modeled as a hidden source, to the cortex. The connection from the basal ganglia to the right inferior frontal gyrus was significantly decreased by subthalamic stimulation. Beyond motor inhibition, our study thus strongly suggests that the mechanisms of action of high-frequency subthalamic stimulation are not restricted to the subthalamic nucleus, but also involve the modulation of distributed subcortical–cortical networks. |
format | Online Article Text |
id | pubmed-5315551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-53155512017-02-27 Modulation of motor inhibition by subthalamic stimulation in obsessive-compulsive disorder Kibleur, A Gras-Combe, G Benis, D Bastin, J Bougerol, T Chabardès, S Polosan, M David, O Transl Psychiatry Original Article High-frequency deep brain stimulation of the subthalamic nucleus can be used to treat severe obsessive-compulsive disorders that are refractory to conventional treatments. The mechanisms of action of this approach possibly rely on the modulation of associative-limbic subcortical–cortical loops, but remain to be fully elucidated. Here in 12 patients, we report the effects of high-frequency stimulation of the subthalamic nucleus on behavior, and on electroencephalographic responses and inferred effective connectivity during motor inhibition processes involved in the stop signal task. First, we found that patients were faster to respond and had slower motor inhibition processes when stimulated. Second, the subthalamic stimulation modulated the amplitude and delayed inhibition-related electroencephalographic responses. The power of reconstructed cortical current densities decreased in the stimulation condition in a parietal–frontal network including cortical regions of the inhibition network such as the superior parts of the inferior frontal gyri and the dorsolateral prefrontal cortex. Finally, dynamic causal modeling revealed that the subthalamic stimulation was more likely to modulate efferent connections from the basal ganglia, modeled as a hidden source, to the cortex. The connection from the basal ganglia to the right inferior frontal gyrus was significantly decreased by subthalamic stimulation. Beyond motor inhibition, our study thus strongly suggests that the mechanisms of action of high-frequency subthalamic stimulation are not restricted to the subthalamic nucleus, but also involve the modulation of distributed subcortical–cortical networks. Nature Publishing Group 2016-10 2016-10-18 /pmc/articles/PMC5315551/ /pubmed/27754484 http://dx.doi.org/10.1038/tp.2016.192 Text en Copyright © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Original Article Kibleur, A Gras-Combe, G Benis, D Bastin, J Bougerol, T Chabardès, S Polosan, M David, O Modulation of motor inhibition by subthalamic stimulation in obsessive-compulsive disorder |
title | Modulation of motor inhibition by subthalamic stimulation in obsessive-compulsive disorder |
title_full | Modulation of motor inhibition by subthalamic stimulation in obsessive-compulsive disorder |
title_fullStr | Modulation of motor inhibition by subthalamic stimulation in obsessive-compulsive disorder |
title_full_unstemmed | Modulation of motor inhibition by subthalamic stimulation in obsessive-compulsive disorder |
title_short | Modulation of motor inhibition by subthalamic stimulation in obsessive-compulsive disorder |
title_sort | modulation of motor inhibition by subthalamic stimulation in obsessive-compulsive disorder |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315551/ https://www.ncbi.nlm.nih.gov/pubmed/27754484 http://dx.doi.org/10.1038/tp.2016.192 |
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