Cargando…

Bioengineering Hearts: Simple yet Complex

PURPOSE OF REVIEW: In this review, we focus on the multiple advancements in the field of cardiovascular regenerative medicine and the state-of-the art of building a heart. An organ is comprised of cells, but cells alone do not comprise an organ. We summarize the components needed, the hurdles, and l...

Descripción completa

Detalles Bibliográficos
Autores principales: Taylor, Doris A., Parikh, Rohan B., Sampaio, Luiz C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315720/
https://www.ncbi.nlm.nih.gov/pubmed/28261549
http://dx.doi.org/10.1007/s40778-017-0075-7
_version_ 1782508712748908544
author Taylor, Doris A.
Parikh, Rohan B.
Sampaio, Luiz C.
author_facet Taylor, Doris A.
Parikh, Rohan B.
Sampaio, Luiz C.
author_sort Taylor, Doris A.
collection PubMed
description PURPOSE OF REVIEW: In this review, we focus on the multiple advancements in the field of cardiovascular regenerative medicine and the state-of-the art of building a heart. An organ is comprised of cells, but cells alone do not comprise an organ. We summarize the components needed, the hurdles, and likely translational steps defining the opportunities for discovery. RECENT FINDINGS: The therapies being developed in regenerative medicine aim not only to repair, but also to regenerate or replace ailing tissues and organs. The first generation of cardiac regenerative medicine was gene therapy. The past decade has focused primarily on cell therapy, particularly for repair after ischemic injury with mixed results. Although cell therapy is promising, it will likely never reverse end-stage heart failure; and thus, the unmet need is, and will remain, for organs. Scientists have now tissue engineering and regenerative medicine concepts to invent alternative therapies for a wide spectrum of diseases encompassing cardiovascular, respiratory, gastrointestinal, hepatic, renal, musculoskeletal, ocular, and neurodegenerative disorders. Current studies focus on potential scaffolds and applying concepts and techniques learned with testbeds to building human sized organs. Special focus has been given to scaffold sources, cells types and sources, and cell integration with scaffolds. The complexity arises in combining them to yield an organ. SUMMARY: Regenerative medicine has emerged as one of the most promising fields of translational research and has the potential to minimize both the need for, and increase the availability of, donor organs. The field is characterized by its integration of biology, physical sciences, and engineering. The proper integration of these fields could lead to off-the-shelf bioartificial organs that are suitable for transplantation. Building a heart will necessarily require a scaffold that can provide cardiac function. We believe that the advent of decellularization methods provides complex, unique, and natural scaffold sources. Ultimately, cell biology and tissue engineering will need to synergize with scaffold biology, finding cell sources and reproducible ways to expand their numbers is an unmet need. But tissue engineering is moving toward whole organ synthesis at an unparalleled pace.
format Online
Article
Text
id pubmed-5315720
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-53157202017-03-02 Bioengineering Hearts: Simple yet Complex Taylor, Doris A. Parikh, Rohan B. Sampaio, Luiz C. Curr Stem Cell Rep Artificial Tissues (A Atala and JG Hunsberger, Section Editors) PURPOSE OF REVIEW: In this review, we focus on the multiple advancements in the field of cardiovascular regenerative medicine and the state-of-the art of building a heart. An organ is comprised of cells, but cells alone do not comprise an organ. We summarize the components needed, the hurdles, and likely translational steps defining the opportunities for discovery. RECENT FINDINGS: The therapies being developed in regenerative medicine aim not only to repair, but also to regenerate or replace ailing tissues and organs. The first generation of cardiac regenerative medicine was gene therapy. The past decade has focused primarily on cell therapy, particularly for repair after ischemic injury with mixed results. Although cell therapy is promising, it will likely never reverse end-stage heart failure; and thus, the unmet need is, and will remain, for organs. Scientists have now tissue engineering and regenerative medicine concepts to invent alternative therapies for a wide spectrum of diseases encompassing cardiovascular, respiratory, gastrointestinal, hepatic, renal, musculoskeletal, ocular, and neurodegenerative disorders. Current studies focus on potential scaffolds and applying concepts and techniques learned with testbeds to building human sized organs. Special focus has been given to scaffold sources, cells types and sources, and cell integration with scaffolds. The complexity arises in combining them to yield an organ. SUMMARY: Regenerative medicine has emerged as one of the most promising fields of translational research and has the potential to minimize both the need for, and increase the availability of, donor organs. The field is characterized by its integration of biology, physical sciences, and engineering. The proper integration of these fields could lead to off-the-shelf bioartificial organs that are suitable for transplantation. Building a heart will necessarily require a scaffold that can provide cardiac function. We believe that the advent of decellularization methods provides complex, unique, and natural scaffold sources. Ultimately, cell biology and tissue engineering will need to synergize with scaffold biology, finding cell sources and reproducible ways to expand their numbers is an unmet need. But tissue engineering is moving toward whole organ synthesis at an unparalleled pace. Springer International Publishing 2017-02-10 2017 /pmc/articles/PMC5315720/ /pubmed/28261549 http://dx.doi.org/10.1007/s40778-017-0075-7 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Artificial Tissues (A Atala and JG Hunsberger, Section Editors)
Taylor, Doris A.
Parikh, Rohan B.
Sampaio, Luiz C.
Bioengineering Hearts: Simple yet Complex
title Bioengineering Hearts: Simple yet Complex
title_full Bioengineering Hearts: Simple yet Complex
title_fullStr Bioengineering Hearts: Simple yet Complex
title_full_unstemmed Bioengineering Hearts: Simple yet Complex
title_short Bioengineering Hearts: Simple yet Complex
title_sort bioengineering hearts: simple yet complex
topic Artificial Tissues (A Atala and JG Hunsberger, Section Editors)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315720/
https://www.ncbi.nlm.nih.gov/pubmed/28261549
http://dx.doi.org/10.1007/s40778-017-0075-7
work_keys_str_mv AT taylordorisa bioengineeringheartssimpleyetcomplex
AT parikhrohanb bioengineeringheartssimpleyetcomplex
AT sampaioluizc bioengineeringheartssimpleyetcomplex