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Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson’s disease

The formation of oligomers and aggregates of overexpressed or mutant α-synuclein play a role in the degeneration of dopaminergic neurons in Parkinson’s disease by causing dysfunction of mitochondria, reflected in their disturbed mobility and production of ROS. The mode of action and mechanisms under...

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Detalles Bibliográficos
Autores principales:	Melo, T. Q., van Zomeren, K. C., Ferrari, M. F. R., Boddeke, H. W. G. M., Copray, J. C. V. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315729/ https://www.ncbi.nlm.nih.gov/pubmed/27866262 http://dx.doi.org/10.1007/s00221-016-4836-9

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