Update on Neoadjuvant Regimens for Patients with Operable Oesophageal/Gastrooesophageal Junction Adenocarcinomas and Squamous Cell Carcinomas

Survival outcomes following multimodal treatment of operable oesophageal and gastrooesophageal cancer remain disappointingly poor. Although an appreciation of the impact of both tumour location and histological subtype is now shaping the design of clinical trials, there has been a lack of consensus...

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Autores principales: Cox, Samantha J., O’Cathail, Sean M., Coles, Bernadette, Crosby, Tom, Mukherjee, Somnath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Gastrointestinal Cancers (J Meyer, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315732/
https://www.ncbi.nlm.nih.gov/pubmed/28213876
http://dx.doi.org/10.1007/s11912-017-0559-8
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author Cox, Samantha J.
O’Cathail, Sean M.
Coles, Bernadette
Crosby, Tom
Mukherjee, Somnath
author_facet Cox, Samantha J.
O’Cathail, Sean M.
Coles, Bernadette
Crosby, Tom
Mukherjee, Somnath
author_sort Cox, Samantha J.
collection PubMed
description Survival outcomes following multimodal treatment of operable oesophageal and gastrooesophageal cancer remain disappointingly poor. Although an appreciation of the impact of both tumour location and histological subtype is now shaping the design of clinical trials, there has been a lack of consensus of the optimal neoadjuvant treatment strategy. This update article will review recent advances in the use of both neoadjuvant chemotherapy and chemoradiotherapy. The emerging role of PET imaging to direct appropriate neoadjuvant treatment regimens and the additive benefit of biological agents are also discussed.
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spelling pubmed-53157322017-03-09 Update on Neoadjuvant Regimens for Patients with Operable Oesophageal/Gastrooesophageal Junction Adenocarcinomas and Squamous Cell Carcinomas Cox, Samantha J. O’Cathail, Sean M. Coles, Bernadette Crosby, Tom Mukherjee, Somnath Curr Oncol Rep Gastrointestinal Cancers (J Meyer, Section Editor) Survival outcomes following multimodal treatment of operable oesophageal and gastrooesophageal cancer remain disappointingly poor. Although an appreciation of the impact of both tumour location and histological subtype is now shaping the design of clinical trials, there has been a lack of consensus of the optimal neoadjuvant treatment strategy. This update article will review recent advances in the use of both neoadjuvant chemotherapy and chemoradiotherapy. The emerging role of PET imaging to direct appropriate neoadjuvant treatment regimens and the additive benefit of biological agents are also discussed. Springer US 2017-02-17 2017 /pmc/articles/PMC5315732/ /pubmed/28213876 http://dx.doi.org/10.1007/s11912-017-0559-8 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Gastrointestinal Cancers (J Meyer, Section Editor)
Cox, Samantha J.
O’Cathail, Sean M.
Coles, Bernadette
Crosby, Tom
Mukherjee, Somnath
Update on Neoadjuvant Regimens for Patients with Operable Oesophageal/Gastrooesophageal Junction Adenocarcinomas and Squamous Cell Carcinomas
title Update on Neoadjuvant Regimens for Patients with Operable Oesophageal/Gastrooesophageal Junction Adenocarcinomas and Squamous Cell Carcinomas
title_full Update on Neoadjuvant Regimens for Patients with Operable Oesophageal/Gastrooesophageal Junction Adenocarcinomas and Squamous Cell Carcinomas
title_fullStr Update on Neoadjuvant Regimens for Patients with Operable Oesophageal/Gastrooesophageal Junction Adenocarcinomas and Squamous Cell Carcinomas
title_full_unstemmed Update on Neoadjuvant Regimens for Patients with Operable Oesophageal/Gastrooesophageal Junction Adenocarcinomas and Squamous Cell Carcinomas
title_short Update on Neoadjuvant Regimens for Patients with Operable Oesophageal/Gastrooesophageal Junction Adenocarcinomas and Squamous Cell Carcinomas
title_sort update on neoadjuvant regimens for patients with operable oesophageal/gastrooesophageal junction adenocarcinomas and squamous cell carcinomas
topic Gastrointestinal Cancers (J Meyer, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315732/
https://www.ncbi.nlm.nih.gov/pubmed/28213876
http://dx.doi.org/10.1007/s11912-017-0559-8
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