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African ancestry is associated with facial melasma in women: a cross-sectional study
BACKGROUND: Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in diffe...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316149/ https://www.ncbi.nlm.nih.gov/pubmed/28212612 http://dx.doi.org/10.1186/s12881-017-0378-7 |
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author | D’Elia, Maria Paula Barbieri Brandão, Marcela Calixto de Andrade Ramos, Bruna Ribeiro da Silva, Márcia Guimarães Miot, Luciane Donida Bartoli dos Santos, Sidney Emanuel Batista Miot, Hélio Amante |
author_facet | D’Elia, Maria Paula Barbieri Brandão, Marcela Calixto de Andrade Ramos, Bruna Ribeiro da Silva, Márcia Guimarães Miot, Luciane Donida Bartoli dos Santos, Sidney Emanuel Batista Miot, Hélio Amante |
author_sort | D’Elia, Maria Paula Barbieri |
collection | PubMed |
description | BACKGROUND: Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Here, we evaluated the association between genetic ancestry and facial melasma. METHODS: A cross-sectional study involving women with melasma and an age-matched control group from outpatients at FMB-Unesp, Botucatu-SP, Brazil was performed. DNA was extracted from oral mucosa swabs and ancestry determined by studying 61 INDELs. The genetic ancestry components were adjusted by other known risk factors by multiple logistic regression. RESULTS: We evaluated 119 women with facial melasma and 119 controls. Mean age was 39 ± 9 years. Mean age at beginning of disease was 27 ± 8 years. Pregnancy (40%), sun exposure (37%), and hormonal oral contraception (22%) were the most frequently reported melasma triggers. All subjects presented admixed ancestry, African and European genetic contributions were significantly different between cases and controls (respectively 10% vs 6%; 77% vs 82%; p < 0.05). African ancestry (OR = 1.04; 95% CI 1.01 to 1.07), first generation family history (OR = 3.04; 95% CI 1.56 to 5.94), low education level (OR = 4.04; 95% CI 1.56 to 5.94), and use of antidepressants by individuals with affected family members (OR = 6.15; 95% CI 1.13 to 33.37) were associated with melasma, independently of other known risk factors. CONCLUSIONS: Facial melasma was independently associated with African ancestry in a highly admixed population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12881-017-0378-7) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5316149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53161492017-02-24 African ancestry is associated with facial melasma in women: a cross-sectional study D’Elia, Maria Paula Barbieri Brandão, Marcela Calixto de Andrade Ramos, Bruna Ribeiro da Silva, Márcia Guimarães Miot, Luciane Donida Bartoli dos Santos, Sidney Emanuel Batista Miot, Hélio Amante BMC Med Genet Research Article BACKGROUND: Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Here, we evaluated the association between genetic ancestry and facial melasma. METHODS: A cross-sectional study involving women with melasma and an age-matched control group from outpatients at FMB-Unesp, Botucatu-SP, Brazil was performed. DNA was extracted from oral mucosa swabs and ancestry determined by studying 61 INDELs. The genetic ancestry components were adjusted by other known risk factors by multiple logistic regression. RESULTS: We evaluated 119 women with facial melasma and 119 controls. Mean age was 39 ± 9 years. Mean age at beginning of disease was 27 ± 8 years. Pregnancy (40%), sun exposure (37%), and hormonal oral contraception (22%) were the most frequently reported melasma triggers. All subjects presented admixed ancestry, African and European genetic contributions were significantly different between cases and controls (respectively 10% vs 6%; 77% vs 82%; p < 0.05). African ancestry (OR = 1.04; 95% CI 1.01 to 1.07), first generation family history (OR = 3.04; 95% CI 1.56 to 5.94), low education level (OR = 4.04; 95% CI 1.56 to 5.94), and use of antidepressants by individuals with affected family members (OR = 6.15; 95% CI 1.13 to 33.37) were associated with melasma, independently of other known risk factors. CONCLUSIONS: Facial melasma was independently associated with African ancestry in a highly admixed population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12881-017-0378-7) contains supplementary material, which is available to authorized users. BioMed Central 2017-02-17 /pmc/articles/PMC5316149/ /pubmed/28212612 http://dx.doi.org/10.1186/s12881-017-0378-7 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article D’Elia, Maria Paula Barbieri Brandão, Marcela Calixto de Andrade Ramos, Bruna Ribeiro da Silva, Márcia Guimarães Miot, Luciane Donida Bartoli dos Santos, Sidney Emanuel Batista Miot, Hélio Amante African ancestry is associated with facial melasma in women: a cross-sectional study |
title | African ancestry is associated with facial melasma in women: a cross-sectional study |
title_full | African ancestry is associated with facial melasma in women: a cross-sectional study |
title_fullStr | African ancestry is associated with facial melasma in women: a cross-sectional study |
title_full_unstemmed | African ancestry is associated with facial melasma in women: a cross-sectional study |
title_short | African ancestry is associated with facial melasma in women: a cross-sectional study |
title_sort | african ancestry is associated with facial melasma in women: a cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316149/ https://www.ncbi.nlm.nih.gov/pubmed/28212612 http://dx.doi.org/10.1186/s12881-017-0378-7 |
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