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African ancestry is associated with facial melasma in women: a cross-sectional study

BACKGROUND: Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in diffe...

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Autores principales: D’Elia, Maria Paula Barbieri, Brandão, Marcela Calixto, de Andrade Ramos, Bruna Ribeiro, da Silva, Márcia Guimarães, Miot, Luciane Donida Bartoli, dos Santos, Sidney Emanuel Batista, Miot, Hélio Amante
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316149/
https://www.ncbi.nlm.nih.gov/pubmed/28212612
http://dx.doi.org/10.1186/s12881-017-0378-7
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author D’Elia, Maria Paula Barbieri
Brandão, Marcela Calixto
de Andrade Ramos, Bruna Ribeiro
da Silva, Márcia Guimarães
Miot, Luciane Donida Bartoli
dos Santos, Sidney Emanuel Batista
Miot, Hélio Amante
author_facet D’Elia, Maria Paula Barbieri
Brandão, Marcela Calixto
de Andrade Ramos, Bruna Ribeiro
da Silva, Márcia Guimarães
Miot, Luciane Donida Bartoli
dos Santos, Sidney Emanuel Batista
Miot, Hélio Amante
author_sort D’Elia, Maria Paula Barbieri
collection PubMed
description BACKGROUND: Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Here, we evaluated the association between genetic ancestry and facial melasma. METHODS: A cross-sectional study involving women with melasma and an age-matched control group from outpatients at FMB-Unesp, Botucatu-SP, Brazil was performed. DNA was extracted from oral mucosa swabs and ancestry determined by studying 61 INDELs. The genetic ancestry components were adjusted by other known risk factors by multiple logistic regression. RESULTS: We evaluated 119 women with facial melasma and 119 controls. Mean age was 39 ± 9 years. Mean age at beginning of disease was 27 ± 8 years. Pregnancy (40%), sun exposure (37%), and hormonal oral contraception (22%) were the most frequently reported melasma triggers. All subjects presented admixed ancestry, African and European genetic contributions were significantly different between cases and controls (respectively 10% vs 6%; 77% vs 82%; p < 0.05). African ancestry (OR = 1.04; 95% CI 1.01 to 1.07), first generation family history (OR = 3.04; 95% CI 1.56 to 5.94), low education level (OR = 4.04; 95% CI 1.56 to 5.94), and use of antidepressants by individuals with affected family members (OR = 6.15; 95% CI 1.13 to 33.37) were associated with melasma, independently of other known risk factors. CONCLUSIONS: Facial melasma was independently associated with African ancestry in a highly admixed population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12881-017-0378-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-53161492017-02-24 African ancestry is associated with facial melasma in women: a cross-sectional study D’Elia, Maria Paula Barbieri Brandão, Marcela Calixto de Andrade Ramos, Bruna Ribeiro da Silva, Márcia Guimarães Miot, Luciane Donida Bartoli dos Santos, Sidney Emanuel Batista Miot, Hélio Amante BMC Med Genet Research Article BACKGROUND: Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Here, we evaluated the association between genetic ancestry and facial melasma. METHODS: A cross-sectional study involving women with melasma and an age-matched control group from outpatients at FMB-Unesp, Botucatu-SP, Brazil was performed. DNA was extracted from oral mucosa swabs and ancestry determined by studying 61 INDELs. The genetic ancestry components were adjusted by other known risk factors by multiple logistic regression. RESULTS: We evaluated 119 women with facial melasma and 119 controls. Mean age was 39 ± 9 years. Mean age at beginning of disease was 27 ± 8 years. Pregnancy (40%), sun exposure (37%), and hormonal oral contraception (22%) were the most frequently reported melasma triggers. All subjects presented admixed ancestry, African and European genetic contributions were significantly different between cases and controls (respectively 10% vs 6%; 77% vs 82%; p < 0.05). African ancestry (OR = 1.04; 95% CI 1.01 to 1.07), first generation family history (OR = 3.04; 95% CI 1.56 to 5.94), low education level (OR = 4.04; 95% CI 1.56 to 5.94), and use of antidepressants by individuals with affected family members (OR = 6.15; 95% CI 1.13 to 33.37) were associated with melasma, independently of other known risk factors. CONCLUSIONS: Facial melasma was independently associated with African ancestry in a highly admixed population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12881-017-0378-7) contains supplementary material, which is available to authorized users. BioMed Central 2017-02-17 /pmc/articles/PMC5316149/ /pubmed/28212612 http://dx.doi.org/10.1186/s12881-017-0378-7 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
D’Elia, Maria Paula Barbieri
Brandão, Marcela Calixto
de Andrade Ramos, Bruna Ribeiro
da Silva, Márcia Guimarães
Miot, Luciane Donida Bartoli
dos Santos, Sidney Emanuel Batista
Miot, Hélio Amante
African ancestry is associated with facial melasma in women: a cross-sectional study
title African ancestry is associated with facial melasma in women: a cross-sectional study
title_full African ancestry is associated with facial melasma in women: a cross-sectional study
title_fullStr African ancestry is associated with facial melasma in women: a cross-sectional study
title_full_unstemmed African ancestry is associated with facial melasma in women: a cross-sectional study
title_short African ancestry is associated with facial melasma in women: a cross-sectional study
title_sort african ancestry is associated with facial melasma in women: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316149/
https://www.ncbi.nlm.nih.gov/pubmed/28212612
http://dx.doi.org/10.1186/s12881-017-0378-7
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