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Genetic diversity and selection of three nuclear genes in Schistosoma japonicum populations

BACKGROUND: The blood fluke, Schistosoma japonicum still causes severe disease in China, the Philippines and Indonesia. Although there have been some studies the molecular epidemiology of this persistent and harmful parasite, few have explored the possibility and implications of selection in S. japo...

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Autores principales: Li, Yaqi, Yin, Mingbo, Wu, Qunfeng, McManus, Donald P., Blair, David, Li, Hongyan, Xu, Bin, Mo, Xiaojin, Feng, Zheng, Hu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316221/
https://www.ncbi.nlm.nih.gov/pubmed/28212676
http://dx.doi.org/10.1186/s13071-017-2033-8
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author Li, Yaqi
Yin, Mingbo
Wu, Qunfeng
McManus, Donald P.
Blair, David
Li, Hongyan
Xu, Bin
Mo, Xiaojin
Feng, Zheng
Hu, Wei
author_facet Li, Yaqi
Yin, Mingbo
Wu, Qunfeng
McManus, Donald P.
Blair, David
Li, Hongyan
Xu, Bin
Mo, Xiaojin
Feng, Zheng
Hu, Wei
author_sort Li, Yaqi
collection PubMed
description BACKGROUND: The blood fluke, Schistosoma japonicum still causes severe disease in China, the Philippines and Indonesia. Although there have been some studies the molecular epidemiology of this persistent and harmful parasite, few have explored the possibility and implications of selection in S. japonicum populations. METHODS: We analyzed diversity and looked for evidence of selection at three nuclear genes (SjIpp2, SjFabp and SjT22.6) in 13 S. japonicum populations. RESULTS: SjT22.6 was found to exhibit high nucleotide diversity and was under positive selection in the mountainous region of mainland China. As a tegumental protein, its secondary and tertiary structure differed between S. japonicum strains from the mountainous and lakes regions. In contrast, SjIpp2 and SjFabp had relatively low levels of nucleotide diversity and did not show significant departure from neutrality. CONCLUSIONS: As a tegument-associated antigen-encoding gene of S. japonicum, SjT22.6 has high nucleotide diversity and appears to be under positive selection in the mountainous region of mainland China. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13071-017-2033-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-53162212017-02-24 Genetic diversity and selection of three nuclear genes in Schistosoma japonicum populations Li, Yaqi Yin, Mingbo Wu, Qunfeng McManus, Donald P. Blair, David Li, Hongyan Xu, Bin Mo, Xiaojin Feng, Zheng Hu, Wei Parasit Vectors Research BACKGROUND: The blood fluke, Schistosoma japonicum still causes severe disease in China, the Philippines and Indonesia. Although there have been some studies the molecular epidemiology of this persistent and harmful parasite, few have explored the possibility and implications of selection in S. japonicum populations. METHODS: We analyzed diversity and looked for evidence of selection at three nuclear genes (SjIpp2, SjFabp and SjT22.6) in 13 S. japonicum populations. RESULTS: SjT22.6 was found to exhibit high nucleotide diversity and was under positive selection in the mountainous region of mainland China. As a tegumental protein, its secondary and tertiary structure differed between S. japonicum strains from the mountainous and lakes regions. In contrast, SjIpp2 and SjFabp had relatively low levels of nucleotide diversity and did not show significant departure from neutrality. CONCLUSIONS: As a tegument-associated antigen-encoding gene of S. japonicum, SjT22.6 has high nucleotide diversity and appears to be under positive selection in the mountainous region of mainland China. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13071-017-2033-8) contains supplementary material, which is available to authorized users. BioMed Central 2017-02-17 /pmc/articles/PMC5316221/ /pubmed/28212676 http://dx.doi.org/10.1186/s13071-017-2033-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Li, Yaqi
Yin, Mingbo
Wu, Qunfeng
McManus, Donald P.
Blair, David
Li, Hongyan
Xu, Bin
Mo, Xiaojin
Feng, Zheng
Hu, Wei
Genetic diversity and selection of three nuclear genes in Schistosoma japonicum populations
title Genetic diversity and selection of three nuclear genes in Schistosoma japonicum populations
title_full Genetic diversity and selection of three nuclear genes in Schistosoma japonicum populations
title_fullStr Genetic diversity and selection of three nuclear genes in Schistosoma japonicum populations
title_full_unstemmed Genetic diversity and selection of three nuclear genes in Schistosoma japonicum populations
title_short Genetic diversity and selection of three nuclear genes in Schistosoma japonicum populations
title_sort genetic diversity and selection of three nuclear genes in schistosoma japonicum populations
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316221/
https://www.ncbi.nlm.nih.gov/pubmed/28212676
http://dx.doi.org/10.1186/s13071-017-2033-8
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