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Creatine Revealed Anticonvulsant Properties on Chemically and Electrically Induced Seizures in Mice

Creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. Creatine supplements have shown beneficial effects on neurological disorders including Parkinson׳s disease, Huntington›s disease, amyotrophic lateral sclerosis, as...

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Autores principales: Shafaroodi, Hamed, Shahbek, Farnaz, Faizi, Mehrdad, Ebrahimi, Farzad, Moezi, Leila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316263/
https://www.ncbi.nlm.nih.gov/pubmed/28243281
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author Shafaroodi, Hamed
Shahbek, Farnaz
Faizi, Mehrdad
Ebrahimi, Farzad
Moezi, Leila
author_facet Shafaroodi, Hamed
Shahbek, Farnaz
Faizi, Mehrdad
Ebrahimi, Farzad
Moezi, Leila
author_sort Shafaroodi, Hamed
collection PubMed
description Creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. Creatine supplements have shown beneficial effects on neurological disorders including Parkinson׳s disease, Huntington›s disease, amyotrophic lateral sclerosis, as well as Alzheimer›s disease and stroke. However, the potential benefits of creatine for patients with convulsive disorders remain poorly defined. While some authors did not suggest any anti- or pro-convulsant roles for creatine treatment, others suggest that creatine may be an anticonvulsant agent. In this study, we investigated the effects of creatine on seizures in mice. Three models were used to explore the role of creatine on seizures in mice including intravenous pentylenetetrazole (PTZ), intraperitoneal PTZ, and electroshock models. Acute creatine treatment (10, 20, 40 and 80 mg/Kg) significantly increased the clonic seizure threshold in the intravenous PTZ model. Sub-chronic administration of creatine (10 and 20 mg/Kg) revealed a significant anticonvulsant effect in intravenous PTZ model. Acute creatine administration (10, 20 and 40 mg/Kg) significantly decreased the frequency of clonic seizures in the intraperitoneal PTZ model. Besides, acute creatine (40 and 80 mg/Kg) decreased the incidence of tonic seizures after electroshock. In conclusion, creatine exerts anticonvulsant effects in three seizure models; therefore, it may act as a potential drug to help patients with convulsions. However, further investigations should be done to clarify these results more.
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spelling pubmed-53162632017-02-27 Creatine Revealed Anticonvulsant Properties on Chemically and Electrically Induced Seizures in Mice Shafaroodi, Hamed Shahbek, Farnaz Faizi, Mehrdad Ebrahimi, Farzad Moezi, Leila Iran J Pharm Res Original Article Creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. Creatine supplements have shown beneficial effects on neurological disorders including Parkinson׳s disease, Huntington›s disease, amyotrophic lateral sclerosis, as well as Alzheimer›s disease and stroke. However, the potential benefits of creatine for patients with convulsive disorders remain poorly defined. While some authors did not suggest any anti- or pro-convulsant roles for creatine treatment, others suggest that creatine may be an anticonvulsant agent. In this study, we investigated the effects of creatine on seizures in mice. Three models were used to explore the role of creatine on seizures in mice including intravenous pentylenetetrazole (PTZ), intraperitoneal PTZ, and electroshock models. Acute creatine treatment (10, 20, 40 and 80 mg/Kg) significantly increased the clonic seizure threshold in the intravenous PTZ model. Sub-chronic administration of creatine (10 and 20 mg/Kg) revealed a significant anticonvulsant effect in intravenous PTZ model. Acute creatine administration (10, 20 and 40 mg/Kg) significantly decreased the frequency of clonic seizures in the intraperitoneal PTZ model. Besides, acute creatine (40 and 80 mg/Kg) decreased the incidence of tonic seizures after electroshock. In conclusion, creatine exerts anticonvulsant effects in three seizure models; therefore, it may act as a potential drug to help patients with convulsions. However, further investigations should be done to clarify these results more. Shaheed Beheshti University of Medical Sciences 2016 /pmc/articles/PMC5316263/ /pubmed/28243281 Text en © 2016 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shafaroodi, Hamed
Shahbek, Farnaz
Faizi, Mehrdad
Ebrahimi, Farzad
Moezi, Leila
Creatine Revealed Anticonvulsant Properties on Chemically and Electrically Induced Seizures in Mice
title Creatine Revealed Anticonvulsant Properties on Chemically and Electrically Induced Seizures in Mice
title_full Creatine Revealed Anticonvulsant Properties on Chemically and Electrically Induced Seizures in Mice
title_fullStr Creatine Revealed Anticonvulsant Properties on Chemically and Electrically Induced Seizures in Mice
title_full_unstemmed Creatine Revealed Anticonvulsant Properties on Chemically and Electrically Induced Seizures in Mice
title_short Creatine Revealed Anticonvulsant Properties on Chemically and Electrically Induced Seizures in Mice
title_sort creatine revealed anticonvulsant properties on chemically and electrically induced seizures in mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316263/
https://www.ncbi.nlm.nih.gov/pubmed/28243281
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