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Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach

Hepatotoxicity is one of the major reasons for withdrawal of drugs from the market. Therefore, there is a need to screen new drugs for hepatotoxicity in humans at an earlier stage. The aim of this study was to validate human precision-cut liver slices (PCLS) as an ex vivo model to predict drug-induc...

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Detalles Bibliográficos
Autores principales:	Vatakuti, Suresh, Olinga, Peter, Pennings, Jeroen L. A., Groothuis, Geny M. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Organ Toxicity and Mechanisms
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316400/ https://www.ncbi.nlm.nih.gov/pubmed/27344345 http://dx.doi.org/10.1007/s00204-016-1778-8

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