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Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases
Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316459/ https://www.ncbi.nlm.nih.gov/pubmed/28260841 http://dx.doi.org/10.1155/2017/9621724 |
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author | Dreymueller, D. Theodorou, K. Donners, M. Ludwig, A. |
author_facet | Dreymueller, D. Theodorou, K. Donners, M. Ludwig, A. |
author_sort | Dreymueller, D. |
collection | PubMed |
description | Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesion molecules, and receptors for these ligands. This review describes how a disintegrin and metalloproteinases interfere with several steps of cell migration, either by proteolytic cleavage of such molecules or by functions independent of proteolytic activity. |
format | Online Article Text |
id | pubmed-5316459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-53164592017-03-05 Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases Dreymueller, D. Theodorou, K. Donners, M. Ludwig, A. Mediators Inflamm Review Article Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesion molecules, and receptors for these ligands. This review describes how a disintegrin and metalloproteinases interfere with several steps of cell migration, either by proteolytic cleavage of such molecules or by functions independent of proteolytic activity. Hindawi Publishing Corporation 2017 2017-02-05 /pmc/articles/PMC5316459/ /pubmed/28260841 http://dx.doi.org/10.1155/2017/9621724 Text en Copyright © 2017 D. Dreymueller et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Dreymueller, D. Theodorou, K. Donners, M. Ludwig, A. Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases |
title | Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases |
title_full | Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases |
title_fullStr | Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases |
title_full_unstemmed | Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases |
title_short | Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases |
title_sort | fine tuning cell migration by a disintegrin and metalloproteinases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316459/ https://www.ncbi.nlm.nih.gov/pubmed/28260841 http://dx.doi.org/10.1155/2017/9621724 |
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