Cargando…

Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases

Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement,...

Descripción completa

Detalles Bibliográficos
Autores principales: Dreymueller, D., Theodorou, K., Donners, M., Ludwig, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316459/
https://www.ncbi.nlm.nih.gov/pubmed/28260841
http://dx.doi.org/10.1155/2017/9621724
_version_ 1782508840409890816
author Dreymueller, D.
Theodorou, K.
Donners, M.
Ludwig, A.
author_facet Dreymueller, D.
Theodorou, K.
Donners, M.
Ludwig, A.
author_sort Dreymueller, D.
collection PubMed
description Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesion molecules, and receptors for these ligands. This review describes how a disintegrin and metalloproteinases interfere with several steps of cell migration, either by proteolytic cleavage of such molecules or by functions independent of proteolytic activity.
format Online
Article
Text
id pubmed-5316459
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-53164592017-03-05 Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases Dreymueller, D. Theodorou, K. Donners, M. Ludwig, A. Mediators Inflamm Review Article Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies. Both basic cell migration and migration towards chemotactic stimulus consist of changes in cell polarity and cytoskeletal rearrangement, cell detachment from, invasion through, and reattachment to their neighboring cells, and numerous interactions with the extracellular matrix. The different steps of immune cell, tissue cell, or cancer cell migration are tightly coordinated in time and place by growth factors, cytokines/chemokines, adhesion molecules, and receptors for these ligands. This review describes how a disintegrin and metalloproteinases interfere with several steps of cell migration, either by proteolytic cleavage of such molecules or by functions independent of proteolytic activity. Hindawi Publishing Corporation 2017 2017-02-05 /pmc/articles/PMC5316459/ /pubmed/28260841 http://dx.doi.org/10.1155/2017/9621724 Text en Copyright © 2017 D. Dreymueller et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Dreymueller, D.
Theodorou, K.
Donners, M.
Ludwig, A.
Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases
title Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases
title_full Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases
title_fullStr Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases
title_full_unstemmed Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases
title_short Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases
title_sort fine tuning cell migration by a disintegrin and metalloproteinases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316459/
https://www.ncbi.nlm.nih.gov/pubmed/28260841
http://dx.doi.org/10.1155/2017/9621724
work_keys_str_mv AT dreymuellerd finetuningcellmigrationbyadisintegrinandmetalloproteinases
AT theodorouk finetuningcellmigrationbyadisintegrinandmetalloproteinases
AT donnersm finetuningcellmigrationbyadisintegrinandmetalloproteinases
AT ludwiga finetuningcellmigrationbyadisintegrinandmetalloproteinases