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Formulation and Evaluation of New Glimepiride Sublingual Tablets

Oral mucosal delivery of drugs promotes rapid absorption and high bioavailability, with a subsequent immediate onset of pharmacological effect. However, many oral mucosal deliveries are compromised by the possibility of the patient swallowing the active substance before it has been released and abso...

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Autores principales: Al-Madhagi, Wafa, Abdulbari Albarakani, Ahmed, Khaled Alhag, Abobakr, Ahmed Saeed, Zakaria, Mansour Noman, Nahlah, Mohamed, Khaldon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316461/
https://www.ncbi.nlm.nih.gov/pubmed/28261517
http://dx.doi.org/10.1155/2017/3690473
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author Al-Madhagi, Wafa
Abdulbari Albarakani, Ahmed
Khaled Alhag, Abobakr
Ahmed Saeed, Zakaria
Mansour Noman, Nahlah
Mohamed, Khaldon
author_facet Al-Madhagi, Wafa
Abdulbari Albarakani, Ahmed
Khaled Alhag, Abobakr
Ahmed Saeed, Zakaria
Mansour Noman, Nahlah
Mohamed, Khaldon
author_sort Al-Madhagi, Wafa
collection PubMed
description Oral mucosal delivery of drugs promotes rapid absorption and high bioavailability, with a subsequent immediate onset of pharmacological effect. However, many oral mucosal deliveries are compromised by the possibility of the patient swallowing the active substance before it has been released and absorbed locally into the systemic circulation. The aim of this research was to introduce a new glimepiride formula for sublingual administration and rapid drug absorption that can be used in an emergency. The new sublingual formulation was prepared after five trials to prepare the suitable formulation. Two accepted formulations of the new sublingual product were prepared, but one of them with disintegration time of 1.45 min and searching for preferred formulation, the binder, is changed with Flulac and starch slurry to prepare formula with disintegration time of 21 seconds that supports the aim of research to be used in an emergency. The five formulations were done, after adjusting to the binder as Flulac and aerosil with disintegration time of 21 seconds and accepted hardness as well as the weight variation. The assay of a new product (subglimepiride) is 103% which is a promising result, confirming that the formula succeeded. The new product (subglimepiride) is accepted in most quality control tests and it is ready for marketing.
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spelling pubmed-53164612017-03-05 Formulation and Evaluation of New Glimepiride Sublingual Tablets Al-Madhagi, Wafa Abdulbari Albarakani, Ahmed Khaled Alhag, Abobakr Ahmed Saeed, Zakaria Mansour Noman, Nahlah Mohamed, Khaldon J Pharm (Cairo) Research Article Oral mucosal delivery of drugs promotes rapid absorption and high bioavailability, with a subsequent immediate onset of pharmacological effect. However, many oral mucosal deliveries are compromised by the possibility of the patient swallowing the active substance before it has been released and absorbed locally into the systemic circulation. The aim of this research was to introduce a new glimepiride formula for sublingual administration and rapid drug absorption that can be used in an emergency. The new sublingual formulation was prepared after five trials to prepare the suitable formulation. Two accepted formulations of the new sublingual product were prepared, but one of them with disintegration time of 1.45 min and searching for preferred formulation, the binder, is changed with Flulac and starch slurry to prepare formula with disintegration time of 21 seconds that supports the aim of research to be used in an emergency. The five formulations were done, after adjusting to the binder as Flulac and aerosil with disintegration time of 21 seconds and accepted hardness as well as the weight variation. The assay of a new product (subglimepiride) is 103% which is a promising result, confirming that the formula succeeded. The new product (subglimepiride) is accepted in most quality control tests and it is ready for marketing. Hindawi Publishing Corporation 2017 2017-02-05 /pmc/articles/PMC5316461/ /pubmed/28261517 http://dx.doi.org/10.1155/2017/3690473 Text en Copyright © 2017 Wafa Al-Madhagi et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Al-Madhagi, Wafa
Abdulbari Albarakani, Ahmed
Khaled Alhag, Abobakr
Ahmed Saeed, Zakaria
Mansour Noman, Nahlah
Mohamed, Khaldon
Formulation and Evaluation of New Glimepiride Sublingual Tablets
title Formulation and Evaluation of New Glimepiride Sublingual Tablets
title_full Formulation and Evaluation of New Glimepiride Sublingual Tablets
title_fullStr Formulation and Evaluation of New Glimepiride Sublingual Tablets
title_full_unstemmed Formulation and Evaluation of New Glimepiride Sublingual Tablets
title_short Formulation and Evaluation of New Glimepiride Sublingual Tablets
title_sort formulation and evaluation of new glimepiride sublingual tablets
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316461/
https://www.ncbi.nlm.nih.gov/pubmed/28261517
http://dx.doi.org/10.1155/2017/3690473
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