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Formulation and Evaluation of New Glimepiride Sublingual Tablets
Oral mucosal delivery of drugs promotes rapid absorption and high bioavailability, with a subsequent immediate onset of pharmacological effect. However, many oral mucosal deliveries are compromised by the possibility of the patient swallowing the active substance before it has been released and abso...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316461/ https://www.ncbi.nlm.nih.gov/pubmed/28261517 http://dx.doi.org/10.1155/2017/3690473 |
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author | Al-Madhagi, Wafa Abdulbari Albarakani, Ahmed Khaled Alhag, Abobakr Ahmed Saeed, Zakaria Mansour Noman, Nahlah Mohamed, Khaldon |
author_facet | Al-Madhagi, Wafa Abdulbari Albarakani, Ahmed Khaled Alhag, Abobakr Ahmed Saeed, Zakaria Mansour Noman, Nahlah Mohamed, Khaldon |
author_sort | Al-Madhagi, Wafa |
collection | PubMed |
description | Oral mucosal delivery of drugs promotes rapid absorption and high bioavailability, with a subsequent immediate onset of pharmacological effect. However, many oral mucosal deliveries are compromised by the possibility of the patient swallowing the active substance before it has been released and absorbed locally into the systemic circulation. The aim of this research was to introduce a new glimepiride formula for sublingual administration and rapid drug absorption that can be used in an emergency. The new sublingual formulation was prepared after five trials to prepare the suitable formulation. Two accepted formulations of the new sublingual product were prepared, but one of them with disintegration time of 1.45 min and searching for preferred formulation, the binder, is changed with Flulac and starch slurry to prepare formula with disintegration time of 21 seconds that supports the aim of research to be used in an emergency. The five formulations were done, after adjusting to the binder as Flulac and aerosil with disintegration time of 21 seconds and accepted hardness as well as the weight variation. The assay of a new product (subglimepiride) is 103% which is a promising result, confirming that the formula succeeded. The new product (subglimepiride) is accepted in most quality control tests and it is ready for marketing. |
format | Online Article Text |
id | pubmed-5316461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-53164612017-03-05 Formulation and Evaluation of New Glimepiride Sublingual Tablets Al-Madhagi, Wafa Abdulbari Albarakani, Ahmed Khaled Alhag, Abobakr Ahmed Saeed, Zakaria Mansour Noman, Nahlah Mohamed, Khaldon J Pharm (Cairo) Research Article Oral mucosal delivery of drugs promotes rapid absorption and high bioavailability, with a subsequent immediate onset of pharmacological effect. However, many oral mucosal deliveries are compromised by the possibility of the patient swallowing the active substance before it has been released and absorbed locally into the systemic circulation. The aim of this research was to introduce a new glimepiride formula for sublingual administration and rapid drug absorption that can be used in an emergency. The new sublingual formulation was prepared after five trials to prepare the suitable formulation. Two accepted formulations of the new sublingual product were prepared, but one of them with disintegration time of 1.45 min and searching for preferred formulation, the binder, is changed with Flulac and starch slurry to prepare formula with disintegration time of 21 seconds that supports the aim of research to be used in an emergency. The five formulations were done, after adjusting to the binder as Flulac and aerosil with disintegration time of 21 seconds and accepted hardness as well as the weight variation. The assay of a new product (subglimepiride) is 103% which is a promising result, confirming that the formula succeeded. The new product (subglimepiride) is accepted in most quality control tests and it is ready for marketing. Hindawi Publishing Corporation 2017 2017-02-05 /pmc/articles/PMC5316461/ /pubmed/28261517 http://dx.doi.org/10.1155/2017/3690473 Text en Copyright © 2017 Wafa Al-Madhagi et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Al-Madhagi, Wafa Abdulbari Albarakani, Ahmed Khaled Alhag, Abobakr Ahmed Saeed, Zakaria Mansour Noman, Nahlah Mohamed, Khaldon Formulation and Evaluation of New Glimepiride Sublingual Tablets |
title | Formulation and Evaluation of New Glimepiride Sublingual Tablets |
title_full | Formulation and Evaluation of New Glimepiride Sublingual Tablets |
title_fullStr | Formulation and Evaluation of New Glimepiride Sublingual Tablets |
title_full_unstemmed | Formulation and Evaluation of New Glimepiride Sublingual Tablets |
title_short | Formulation and Evaluation of New Glimepiride Sublingual Tablets |
title_sort | formulation and evaluation of new glimepiride sublingual tablets |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316461/ https://www.ncbi.nlm.nih.gov/pubmed/28261517 http://dx.doi.org/10.1155/2017/3690473 |
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