IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP). Other putative DNA receptors have been described, but whether their functions are redundant, tissue-...

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Detalles Bibliográficos
Autores principales: Almine, Jessica F., O'Hare, Craig A. J., Dunphy, Gillian, Haga, Ismar R., Naik, Rangeetha J., Atrih, Abdelmadjid, Connolly, Dympna J., Taylor, Jordan, Kelsall, Ian R., Bowie, Andrew G., Beard, Philippa M., Unterholzner, Leonie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316833/
https://www.ncbi.nlm.nih.gov/pubmed/28194029
http://dx.doi.org/10.1038/ncomms14392

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