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Decreased HHV-6 IgG in Alzheimer’s Disease
Human herpesviruses have previously been implicated in the pathogenesis of Alzheimer’s disease (AD) but whether they are causal, facilitating, or confounding factors is yet to be established. A total of 50 AD subjects and 52 non-demented (ND) controls were analyzed in a multiplex assay for IgG react...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316842/ https://www.ncbi.nlm.nih.gov/pubmed/28265256 http://dx.doi.org/10.3389/fneur.2017.00040 |
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author | Westman, Gabriel Blomberg, Jonas Yun, Zhibing Lannfelt, Lars Ingelsson, Martin Eriksson, Britt-Marie |
author_facet | Westman, Gabriel Blomberg, Jonas Yun, Zhibing Lannfelt, Lars Ingelsson, Martin Eriksson, Britt-Marie |
author_sort | Westman, Gabriel |
collection | PubMed |
description | Human herpesviruses have previously been implicated in the pathogenesis of Alzheimer’s disease (AD) but whether they are causal, facilitating, or confounding factors is yet to be established. A total of 50 AD subjects and 52 non-demented (ND) controls were analyzed in a multiplex assay for IgG reactivity toward herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), and human herpesvirus 6 (HHV-6). The HHV-6 IgG reactivity was significantly lower in AD subjects compared to ND controls, whereas there were no differences in HSV, VZV, or CMV antibody levels between the groups. Analysis of peripheral blood mononuclear cells with a subtype-specific HHV-6 PCR revealed no signs of reactivation, as AD and ND subjects presented with comparable HHV-6 DNA levels in PBMCs, and all positive samples were of subtype B. Whether HHV-6 is a factor in AD remains to be elucidated in future studies. |
format | Online Article Text |
id | pubmed-5316842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-53168422017-03-06 Decreased HHV-6 IgG in Alzheimer’s Disease Westman, Gabriel Blomberg, Jonas Yun, Zhibing Lannfelt, Lars Ingelsson, Martin Eriksson, Britt-Marie Front Neurol Neuroscience Human herpesviruses have previously been implicated in the pathogenesis of Alzheimer’s disease (AD) but whether they are causal, facilitating, or confounding factors is yet to be established. A total of 50 AD subjects and 52 non-demented (ND) controls were analyzed in a multiplex assay for IgG reactivity toward herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), and human herpesvirus 6 (HHV-6). The HHV-6 IgG reactivity was significantly lower in AD subjects compared to ND controls, whereas there were no differences in HSV, VZV, or CMV antibody levels between the groups. Analysis of peripheral blood mononuclear cells with a subtype-specific HHV-6 PCR revealed no signs of reactivation, as AD and ND subjects presented with comparable HHV-6 DNA levels in PBMCs, and all positive samples were of subtype B. Whether HHV-6 is a factor in AD remains to be elucidated in future studies. Frontiers Media S.A. 2017-02-20 /pmc/articles/PMC5316842/ /pubmed/28265256 http://dx.doi.org/10.3389/fneur.2017.00040 Text en Copyright © 2017 Westman, Blomberg, Yun, Lannfelt, Ingelsson and Eriksson. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Westman, Gabriel Blomberg, Jonas Yun, Zhibing Lannfelt, Lars Ingelsson, Martin Eriksson, Britt-Marie Decreased HHV-6 IgG in Alzheimer’s Disease |
title | Decreased HHV-6 IgG in Alzheimer’s Disease |
title_full | Decreased HHV-6 IgG in Alzheimer’s Disease |
title_fullStr | Decreased HHV-6 IgG in Alzheimer’s Disease |
title_full_unstemmed | Decreased HHV-6 IgG in Alzheimer’s Disease |
title_short | Decreased HHV-6 IgG in Alzheimer’s Disease |
title_sort | decreased hhv-6 igg in alzheimer’s disease |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316842/ https://www.ncbi.nlm.nih.gov/pubmed/28265256 http://dx.doi.org/10.3389/fneur.2017.00040 |
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