Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer

Identification of specific oncogenic gene changes has enabled the modern generation of targeted cancer therapeutics. In high-grade serous ovarian cancer (OV), the bulk of genetic changes is not somatic point mutations, but rather somatic copy-number alterations (SCNAs). The impact of SCNAs on tumour...

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Detalles Bibliográficos
Autores principales: Delaney, Joe Ryan, Patel, Chandni B., Willis, Katelyn McCabe, Haghighiabyaneh, Mina, Axelrod, Joshua, Tancioni, Isabelle, Lu, Dan, Bapat, Jaidev, Young, Shanique, Cadassou, Octavia, Bartakova, Alena, Sheth, Parthiv, Haft, Carley, Hui, Sandra, Saenz, Cheryl, Schlaepfer, David D., Harismendy, Olivier, Stupack, Dwayne G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316854/
https://www.ncbi.nlm.nih.gov/pubmed/28198375
http://dx.doi.org/10.1038/ncomms14423

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