Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity

The secretome of cancer and stromal cells generates a microenvironment that contributes to tumour cell invasion and angiogenesis. Here we compare the secretome of human mammary normal and cancer-associated fibroblasts (CAFs). We discover that the chloride intracellular channel protein 3 (CLIC3) is a...

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Detalles Bibliográficos
Autores principales: Hernandez-Fernaud, Juan R., Ruengeler, Elena, Casazza, Andrea, Neilson, Lisa J., Pulleine, Ellie, Santi, Alice, Ismail, Shehab, Lilla, Sergio, Dhayade, Sandeep, MacPherson, Iain R., McNeish, Iain, Ennis, Darren, Ali, Hala, Kugeratski, Fernanda G., Al Khamici, Heba, van den Biggelaar, Maartje, van den Berghe, Peter V.E., Cloix, Catherine, McDonald, Laura, Millan, David, Hoyle, Aoisha, Kuchnio, Anna, Carmeliet, Peter, Valenzuela, Stella M., Blyth, Karen, Yin, Huabing, Mazzone, Massimiliano, Norman, Jim C., Zanivan, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316871/
https://www.ncbi.nlm.nih.gov/pubmed/28198360
http://dx.doi.org/10.1038/ncomms14206

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