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A genome-wide association study yields five novel thyroid cancer risk loci
The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316879/ https://www.ncbi.nlm.nih.gov/pubmed/28195142 http://dx.doi.org/10.1038/ncomms14517 |
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| author | Gudmundsson, Julius Thorleifsson, Gudmar Sigurdsson, Jon K. Stefansdottir, Lilja Jonasson, Jon G. Gudjonsson, Sigurjon A. Gudbjartsson, Daniel F. Masson, Gisli Johannsdottir, Hrefna Halldorsson, Gisli H. Stacey, Simon N. Helgason, Hannes Sulem, Patrick Senter, Leigha He, Huiling Liyanarachchi, Sandya Ringel, Matthew D. Aguillo, Esperanza Panadero, Angeles Prats, Enrique Garcia-Castaño, Almudena De Juan, Ana Rivera, Fernando Xu, Li Kiemeney, Lambertus A. Eyjolfsson, Gudmundur I. Sigurdardottir, Olof Olafsson, Isleifur Kristvinsson, Hoskuldur Netea-Maier, Romana T. Jonsson, Thorvaldur Mayordomo, Jose I. Plantinga, Theo S. Hjartarson, Hannes Hrafnkelsson, Jon Sturgis, Erich M. Thorsteinsdottir, Unnur Rafnar, Thorunn de la Chapelle, Albert Stefansson, Kari |
| author_facet | Gudmundsson, Julius Thorleifsson, Gudmar Sigurdsson, Jon K. Stefansdottir, Lilja Jonasson, Jon G. Gudjonsson, Sigurjon A. Gudbjartsson, Daniel F. Masson, Gisli Johannsdottir, Hrefna Halldorsson, Gisli H. Stacey, Simon N. Helgason, Hannes Sulem, Patrick Senter, Leigha He, Huiling Liyanarachchi, Sandya Ringel, Matthew D. Aguillo, Esperanza Panadero, Angeles Prats, Enrique Garcia-Castaño, Almudena De Juan, Ana Rivera, Fernando Xu, Li Kiemeney, Lambertus A. Eyjolfsson, Gudmundur I. Sigurdardottir, Olof Olafsson, Isleifur Kristvinsson, Hoskuldur Netea-Maier, Romana T. Jonsson, Thorvaldur Mayordomo, Jose I. Plantinga, Theo S. Hjartarson, Hannes Hrafnkelsson, Jon Sturgis, Erich M. Thorsteinsdottir, Unnur Rafnar, Thorunn de la Chapelle, Albert Stefansson, Kari |
| author_sort | Gudmundsson, Julius |
| collection | PubMed |
| description | The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with P(combined)<3 × 10(−8)): 1q42.2 (rs12129938 in PCNXL2), 3q26.2 (rs6793295 a missense mutation in LRCC34 near TERC), 5q22.1 (rs73227498 between NREP and EPB41L4A), 10q24.33 (rs7902587 near OBFC1), and two independently associated variants at 15q22.33 (rs2289261 and rs56062135; both in SMAD3). We also confirm recently published association results from a Chinese study of a variant on 5p15.33 (rs2736100 near the TERT gene) and present a stronger association result for a moderately correlated variant (rs10069690; OR=1.20, P=3.2 × 10(−7)) based on our study of individuals of European ancestry. In combination, these results raise several opportunities for future studies of the pathogenesis of thyroid cancer. |
| format | Online Article Text |
| id | pubmed-5316879 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-53168792017-02-27 A genome-wide association study yields five novel thyroid cancer risk loci Gudmundsson, Julius Thorleifsson, Gudmar Sigurdsson, Jon K. Stefansdottir, Lilja Jonasson, Jon G. Gudjonsson, Sigurjon A. Gudbjartsson, Daniel F. Masson, Gisli Johannsdottir, Hrefna Halldorsson, Gisli H. Stacey, Simon N. Helgason, Hannes Sulem, Patrick Senter, Leigha He, Huiling Liyanarachchi, Sandya Ringel, Matthew D. Aguillo, Esperanza Panadero, Angeles Prats, Enrique Garcia-Castaño, Almudena De Juan, Ana Rivera, Fernando Xu, Li Kiemeney, Lambertus A. Eyjolfsson, Gudmundur I. Sigurdardottir, Olof Olafsson, Isleifur Kristvinsson, Hoskuldur Netea-Maier, Romana T. Jonsson, Thorvaldur Mayordomo, Jose I. Plantinga, Theo S. Hjartarson, Hannes Hrafnkelsson, Jon Sturgis, Erich M. Thorsteinsdottir, Unnur Rafnar, Thorunn de la Chapelle, Albert Stefansson, Kari Nat Commun Article The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with P(combined)<3 × 10(−8)): 1q42.2 (rs12129938 in PCNXL2), 3q26.2 (rs6793295 a missense mutation in LRCC34 near TERC), 5q22.1 (rs73227498 between NREP and EPB41L4A), 10q24.33 (rs7902587 near OBFC1), and two independently associated variants at 15q22.33 (rs2289261 and rs56062135; both in SMAD3). We also confirm recently published association results from a Chinese study of a variant on 5p15.33 (rs2736100 near the TERT gene) and present a stronger association result for a moderately correlated variant (rs10069690; OR=1.20, P=3.2 × 10(−7)) based on our study of individuals of European ancestry. In combination, these results raise several opportunities for future studies of the pathogenesis of thyroid cancer. Nature Publishing Group 2017-02-14 /pmc/articles/PMC5316879/ /pubmed/28195142 http://dx.doi.org/10.1038/ncomms14517 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Gudmundsson, Julius Thorleifsson, Gudmar Sigurdsson, Jon K. Stefansdottir, Lilja Jonasson, Jon G. Gudjonsson, Sigurjon A. Gudbjartsson, Daniel F. Masson, Gisli Johannsdottir, Hrefna Halldorsson, Gisli H. Stacey, Simon N. Helgason, Hannes Sulem, Patrick Senter, Leigha He, Huiling Liyanarachchi, Sandya Ringel, Matthew D. Aguillo, Esperanza Panadero, Angeles Prats, Enrique Garcia-Castaño, Almudena De Juan, Ana Rivera, Fernando Xu, Li Kiemeney, Lambertus A. Eyjolfsson, Gudmundur I. Sigurdardottir, Olof Olafsson, Isleifur Kristvinsson, Hoskuldur Netea-Maier, Romana T. Jonsson, Thorvaldur Mayordomo, Jose I. Plantinga, Theo S. Hjartarson, Hannes Hrafnkelsson, Jon Sturgis, Erich M. Thorsteinsdottir, Unnur Rafnar, Thorunn de la Chapelle, Albert Stefansson, Kari A genome-wide association study yields five novel thyroid cancer risk loci |
| title | A genome-wide association study yields five novel thyroid cancer risk loci |
| title_full | A genome-wide association study yields five novel thyroid cancer risk loci |
| title_fullStr | A genome-wide association study yields five novel thyroid cancer risk loci |
| title_full_unstemmed | A genome-wide association study yields five novel thyroid cancer risk loci |
| title_short | A genome-wide association study yields five novel thyroid cancer risk loci |
| title_sort | genome-wide association study yields five novel thyroid cancer risk loci |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316879/ https://www.ncbi.nlm.nih.gov/pubmed/28195142 http://dx.doi.org/10.1038/ncomms14517 |
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