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Infection-derived lipids elicit an immune deficiency circuit in arthropods

The insect immune deficiency (IMD) pathway resembles the tumour necrosis factor receptor network in mammals and senses diaminopimelic-type peptidoglycans present in Gram-negative bacteria. Whether unidentified chemical moieties activate the IMD signalling cascade remains unknown. Here, we show that...

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Autores principales: Shaw, Dana K., Wang, Xiaowei, Brown, Lindsey J., Chávez, Adela S. Oliva, Reif, Kathryn E., Smith, Alexis A., Scott, Alison J., McClure, Erin E., Boradia, Vishant M., Hammond, Holly L., Sundberg, Eric J., Snyder, Greg A., Liu, Lei, DePonte, Kathleen, Villar, Margarita, Ueti, Massaro W., de la Fuente, José, Ernst, Robert K., Pal, Utpal, Fikrig, Erol, Pedra, Joao H. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316886/
https://www.ncbi.nlm.nih.gov/pubmed/28195158
http://dx.doi.org/10.1038/ncomms14401
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author Shaw, Dana K.
Wang, Xiaowei
Brown, Lindsey J.
Chávez, Adela S. Oliva
Reif, Kathryn E.
Smith, Alexis A.
Scott, Alison J.
McClure, Erin E.
Boradia, Vishant M.
Hammond, Holly L.
Sundberg, Eric J.
Snyder, Greg A.
Liu, Lei
DePonte, Kathleen
Villar, Margarita
Ueti, Massaro W.
de la Fuente, José
Ernst, Robert K.
Pal, Utpal
Fikrig, Erol
Pedra, Joao H. F.
author_facet Shaw, Dana K.
Wang, Xiaowei
Brown, Lindsey J.
Chávez, Adela S. Oliva
Reif, Kathryn E.
Smith, Alexis A.
Scott, Alison J.
McClure, Erin E.
Boradia, Vishant M.
Hammond, Holly L.
Sundberg, Eric J.
Snyder, Greg A.
Liu, Lei
DePonte, Kathleen
Villar, Margarita
Ueti, Massaro W.
de la Fuente, José
Ernst, Robert K.
Pal, Utpal
Fikrig, Erol
Pedra, Joao H. F.
author_sort Shaw, Dana K.
collection PubMed
description The insect immune deficiency (IMD) pathway resembles the tumour necrosis factor receptor network in mammals and senses diaminopimelic-type peptidoglycans present in Gram-negative bacteria. Whether unidentified chemical moieties activate the IMD signalling cascade remains unknown. Here, we show that infection-derived lipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) and 1-palmitoyl-2-oleoyl diacylglycerol (PODAG) stimulate the IMD pathway of ticks. The tick IMD network protects against colonization by three distinct bacteria, that is the Lyme disease spirochete Borrelia burgdorferi and the rickettsial agents Anaplasma phagocytophilum and A. marginale. Cell signalling ensues in the absence of transmembrane peptidoglycan recognition proteins and the adaptor molecules Fas-associated protein with a death domain (FADD) and IMD. Conversely, biochemical interactions occur between x-linked inhibitor of apoptosis protein (XIAP), an E3 ubiquitin ligase, and the E2 conjugating enzyme Bendless. We propose the existence of two functionally distinct IMD networks, one in insects and another in ticks.
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spelling pubmed-53168862017-02-27 Infection-derived lipids elicit an immune deficiency circuit in arthropods Shaw, Dana K. Wang, Xiaowei Brown, Lindsey J. Chávez, Adela S. Oliva Reif, Kathryn E. Smith, Alexis A. Scott, Alison J. McClure, Erin E. Boradia, Vishant M. Hammond, Holly L. Sundberg, Eric J. Snyder, Greg A. Liu, Lei DePonte, Kathleen Villar, Margarita Ueti, Massaro W. de la Fuente, José Ernst, Robert K. Pal, Utpal Fikrig, Erol Pedra, Joao H. F. Nat Commun Article The insect immune deficiency (IMD) pathway resembles the tumour necrosis factor receptor network in mammals and senses diaminopimelic-type peptidoglycans present in Gram-negative bacteria. Whether unidentified chemical moieties activate the IMD signalling cascade remains unknown. Here, we show that infection-derived lipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) and 1-palmitoyl-2-oleoyl diacylglycerol (PODAG) stimulate the IMD pathway of ticks. The tick IMD network protects against colonization by three distinct bacteria, that is the Lyme disease spirochete Borrelia burgdorferi and the rickettsial agents Anaplasma phagocytophilum and A. marginale. Cell signalling ensues in the absence of transmembrane peptidoglycan recognition proteins and the adaptor molecules Fas-associated protein with a death domain (FADD) and IMD. Conversely, biochemical interactions occur between x-linked inhibitor of apoptosis protein (XIAP), an E3 ubiquitin ligase, and the E2 conjugating enzyme Bendless. We propose the existence of two functionally distinct IMD networks, one in insects and another in ticks. Nature Publishing Group 2017-02-14 /pmc/articles/PMC5316886/ /pubmed/28195158 http://dx.doi.org/10.1038/ncomms14401 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Shaw, Dana K.
Wang, Xiaowei
Brown, Lindsey J.
Chávez, Adela S. Oliva
Reif, Kathryn E.
Smith, Alexis A.
Scott, Alison J.
McClure, Erin E.
Boradia, Vishant M.
Hammond, Holly L.
Sundberg, Eric J.
Snyder, Greg A.
Liu, Lei
DePonte, Kathleen
Villar, Margarita
Ueti, Massaro W.
de la Fuente, José
Ernst, Robert K.
Pal, Utpal
Fikrig, Erol
Pedra, Joao H. F.
Infection-derived lipids elicit an immune deficiency circuit in arthropods
title Infection-derived lipids elicit an immune deficiency circuit in arthropods
title_full Infection-derived lipids elicit an immune deficiency circuit in arthropods
title_fullStr Infection-derived lipids elicit an immune deficiency circuit in arthropods
title_full_unstemmed Infection-derived lipids elicit an immune deficiency circuit in arthropods
title_short Infection-derived lipids elicit an immune deficiency circuit in arthropods
title_sort infection-derived lipids elicit an immune deficiency circuit in arthropods
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316886/
https://www.ncbi.nlm.nih.gov/pubmed/28195158
http://dx.doi.org/10.1038/ncomms14401
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