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Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014
In 2014, a total of 2,976 Enterobacteriaceae isolates with decreased susceptibility to carbapenems were received at the French Associated National Reference Center for Antibiotic Resistance (NRC) and were characterised for their molecular resistance mechanism to carbapenems and compared with results...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316908/ https://www.ncbi.nlm.nih.gov/pubmed/28205502 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.6.30461 |
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author | Dortet, Laurent Cuzon, Gaëlle Ponties, Valérie Nordmann, Patrice |
author_facet | Dortet, Laurent Cuzon, Gaëlle Ponties, Valérie Nordmann, Patrice |
author_sort | Dortet, Laurent |
collection | PubMed |
description | In 2014, a total of 2,976 Enterobacteriaceae isolates with decreased susceptibility to carbapenems were received at the French Associated National Reference Center for Antibiotic Resistance (NRC) and were characterised for their molecular resistance mechanism to carbapenems and compared with results obtained during 2012 and 2013.The overall number of enterobacterial isolates with decreased susceptibility to carbapenems received at the NRC rapidly increased (more than twofold in two years) with a growing proportion of carbapenemase producers (23.1% in 2012 vs 28.6% in 2013 vs 36.2% in 2014). Between 2012 and 2014, the main carbapenemase type was OXA-48, with an increase in OXA-48 variants (mostly OXA-181) and NDM producers, whereas the number KPC producers decreased. We identified a potential spread of OXA-181 producers in the tropical region of Africa. Finally, OXA-48 and OXA-48-related enzymes remained the predominant carbapenemases in France. The number of carbapenemase-producing Escherischia coli isolates was multiplied by fivefold between 2012 and 2014, suggesting a possible dissemination in the community. |
format | Online Article Text |
id | pubmed-5316908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | European Centre for Disease Prevention and Control (ECDC) |
record_format | MEDLINE/PubMed |
spelling | pubmed-53169082017-02-28 Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014 Dortet, Laurent Cuzon, Gaëlle Ponties, Valérie Nordmann, Patrice Euro Surveill Surveillance and Outbreak Report In 2014, a total of 2,976 Enterobacteriaceae isolates with decreased susceptibility to carbapenems were received at the French Associated National Reference Center for Antibiotic Resistance (NRC) and were characterised for their molecular resistance mechanism to carbapenems and compared with results obtained during 2012 and 2013.The overall number of enterobacterial isolates with decreased susceptibility to carbapenems received at the NRC rapidly increased (more than twofold in two years) with a growing proportion of carbapenemase producers (23.1% in 2012 vs 28.6% in 2013 vs 36.2% in 2014). Between 2012 and 2014, the main carbapenemase type was OXA-48, with an increase in OXA-48 variants (mostly OXA-181) and NDM producers, whereas the number KPC producers decreased. We identified a potential spread of OXA-181 producers in the tropical region of Africa. Finally, OXA-48 and OXA-48-related enzymes remained the predominant carbapenemases in France. The number of carbapenemase-producing Escherischia coli isolates was multiplied by fivefold between 2012 and 2014, suggesting a possible dissemination in the community. European Centre for Disease Prevention and Control (ECDC) 2017-02-09 /pmc/articles/PMC5316908/ /pubmed/28205502 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.6.30461 Text en This article is copyright of The Authors, 2017. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
spellingShingle | Surveillance and Outbreak Report Dortet, Laurent Cuzon, Gaëlle Ponties, Valérie Nordmann, Patrice Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014 |
title | Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014 |
title_full | Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014 |
title_fullStr | Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014 |
title_full_unstemmed | Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014 |
title_short | Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014 |
title_sort | trends in carbapenemase-producing enterobacteriaceae, france, 2012 to 2014 |
topic | Surveillance and Outbreak Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316908/ https://www.ncbi.nlm.nih.gov/pubmed/28205502 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.6.30461 |
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