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Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina

Retinitis pigmentosa (RP) encompasses a group of retinal diseases resulting in photoreceptor loss and blindness. We have previously shown in the rd10 mouse model of RP, that rd10 microglia drive degeneration of viable neurons. Norgestrel, a progesterone analogue, primes viable neurons against potent...

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Detalles Bibliográficos
Autores principales:	Roche, Sarah L., Wyse-Jackson, Alice C., Ruiz-Lopez, Ana M., Byrne, Ashleigh M., Cotter, Thomas G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316933/ https://www.ncbi.nlm.nih.gov/pubmed/28216676 http://dx.doi.org/10.1038/srep43067

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