Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening

Leukotrienes (LTs) are pro-inflammatory lipid mediators derived from arachidonic acid (AA) with roles in inflammatory and allergic diseases. The biosynthesis of LTs is initiated by transfer of AA via the 5-lipoxygenase-activating protein (FLAP) to 5-lipoxygenase (5-LO). FLAP inhibition abolishes LT...

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Detalles Bibliográficos
Autores principales: Temml, Veronika, Garscha, Ulrike, Romp, Erik, Schubert, Gregor, Gerstmeier, Jana, Kutil, Zsofia, Matuszczak, Barbara, Waltenberger, Birgit, Stuppner, Hermann, Werz, Oliver, Schuster, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317001/
https://www.ncbi.nlm.nih.gov/pubmed/28218273
http://dx.doi.org/10.1038/srep42751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317001/
https://www.ncbi.nlm.nih.gov/pubmed/28218273
http://dx.doi.org/10.1038/srep42751

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