Cargando…

Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening

Leukotrienes (LTs) are pro-inflammatory lipid mediators derived from arachidonic acid (AA) with roles in inflammatory and allergic diseases. The biosynthesis of LTs is initiated by transfer of AA via the 5-lipoxygenase-activating protein (FLAP) to 5-lipoxygenase (5-LO). FLAP inhibition abolishes LT...

Descripción completa

Detalles Bibliográficos
Autores principales:	Temml, Veronika, Garscha, Ulrike, Romp, Erik, Schubert, Gregor, Gerstmeier, Jana, Kutil, Zsofia, Matuszczak, Barbara, Waltenberger, Birgit, Stuppner, Hermann, Werz, Oliver, Schuster, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317001/ https://www.ncbi.nlm.nih.gov/pubmed/28218273 http://dx.doi.org/10.1038/srep42751

Ejemplares similares

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase
por: Garscha, Ulrike, et al.
Publicado: (2017)

Synthesis and structure–activity relationships for some novel diflapolin derivatives with benzimidazole subunit
por: Vieider, Lisa, et al.
Publicado: (2022)

Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis
por: Gerstmeier, Jana, et al.
Publicado: (2019)

Synthesis, Biological Evaluation and Structure–Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors
por: Vieider, Lisa, et al.
Publicado: (2018)

Impact of Wines and Wine Constituents on Cyclooxygenase-1, Cyclooxygenase-2, and 5-Lipoxygenase Catalytic Activity
por: Kutil, Zsofia, et al.
Publicado: (2014)

Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A(4) Hydrolase
por: Teder, Tarvi, et al.
Publicado: (2023)

Structure-based molecular modeling in SAR analysis and lead optimization
por: Temml, Veronika, et al.
Publicado: (2021)

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase
por: Pein, Helmut, et al.
Publicado: (2018)

Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase
por: Meirer, Karin, et al.
Publicado: (2016)

Quinazoline-4(3H)-one-7-carboxamide Derivatives as Human Soluble Epoxide Hydrolase Inhibitors with Developable 5-Lipoxygenase Activating Protein Inhibition
por: Turanlı, Sümeyye, et al.
Publicado: (2022)

Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E(2) Synthase-1 (mPGES-1)
por: Waltenberger, Birgit, et al.
Publicado: (2011)

Repositioning of Quinazolinedione-Based Compounds on Soluble Epoxide Hydrolase (sEH) through 3D Structure-Based Pharmacophore Model-Driven Investigation
por: Gazzillo, Erica, et al.
Publicado: (2022)

Prospective performance evaluation of selected common virtual screening tools. Case study: Cyclooxygenase (COX) 1 and 2
por: Kaserer, Teresa, et al.
Publicado: (2015)

Combination of In Silico and In Vitro Screening to Identify Novel Glutamate Carboxypeptidase II Inhibitors
por: Temml, Veronika, et al.
Publicado: (2023)

Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction
por: Mayr, Fabian, et al.
Publicado: (2020)

Soluble Epoxide Hydrolase in Atherosclerosis
por: Wang, Yi-Xin Jim, et al.
Publicado: (2010)

Screening and Biological Evaluation of Soluble Epoxide Hydrolase Inhibitors: Assessing the Role of Hydrophobicity in the Pharmacophore-Guided Search of Novel Hits
por: Vázquez, Javier, et al.
Publicado: (2023)

Soluble Epoxide Hydrolase and Diabetes Complications
por: Anita, Natasha Z., et al.
Publicado: (2022)

Predicting cyclooxygenase inhibition by three-dimensional pharmacophoric profiling. Part II: Identification of enzyme inhibitors from Prasaplai, a Thai traditional medicine
por: Waltenberger, Birgit, et al.
Publicado: (2011)

Benzoxazolone-5-Urea Derivatives as Human Soluble Epoxide Hydrolase (sEH) Inhibitors
por: Gur Maz, Tugce, et al.
Publicado: (2023)

Pharmacophore-based discovery of a novel cytosolic phospholipase A(2)α inhibitor
por: Noha, Stefan M., et al.
Publicado: (2012)

Discovery of New Liver X Receptor Agonists by Pharmacophore Modeling and Shape-Based Virtual Screening
por: Temml, Veronika, et al.
Publicado: (2014)

Inhibition of Soluble Epoxide Hydrolase for Renal Health
por: Liu, Jun-Yan
Publicado: (2019)

Soluble Epoxide Hydrolase and Brain Cholesterol Metabolism
por: Domingues, Michelle Flores, et al.
Publicado: (2020)

Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase()
por: Temml, Veronika, et al.
Publicado: (2013)

Evaluation of fish models of soluble epoxide hydrolase inhibition.
por: Newman, J W, et al.
Publicado: (2001)

Disrupting Dimerization Translocates Soluble Epoxide Hydrolase to Peroxisomes
por: Nelson, Jonathan W., et al.
Publicado: (2016)

Editorial: Clinical Paths for Soluble Epoxide Hydrolase Inhibitors
por: Imig, John D., et al.
Publicado: (2020)

The role of soluble epoxide hydrolase and its inhibitors in depression
por: Borsini, Alessandra
Publicado: (2021)

Identification of Novel β-Tubulin Inhibitors Using a Combined In Silico/In Vitro Approach
por: Horgan, Mark James, et al.
Publicado: (2023)

Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors
por: Kodani, Sean D., et al.
Publicado: (2018)

Epoxide Hydrolases: Multipotential Biocatalysts
por: Bučko, Marek, et al.
Publicado: (2023)

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation
por: Brenneis, Christian, et al.
Publicado: (2011)

Effects of Soluble Epoxide Hydrolase Deficiency on Acute Pancreatitis in Mice
por: Bettaieb, Ahmed, et al.
Publicado: (2014)

Inhibition of soluble epoxide hydrolase increases coronary perfusion in mice
por: Qin, Jun, et al.
Publicado: (2015)

Dysregulation of Soluble Epoxide Hydrolase and Lipidomic Profiles in Anorexia Nervosa
por: Shih, Pei-an Betty, et al.
Publicado: (2015)

Discovery of Novel Soluble Epoxide Hydrolase Inhibitors as Potent Vasodilators
por: Tripathi, Neetika, et al.
Publicado: (2018)

Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future
por: Park, Bomina, et al.
Publicado: (2019)

Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis
por: McReynolds, Cindy B., et al.
Publicado: (2019)

Soluble Epoxide Hydrolase as a Therapeutic Target for Neuropsychiatric Disorders
por: Shan, Jiajing, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2aodl23sgauv7j1paol049sa9e