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Targeted RP9 ablation and mutagenesis in mouse photoreceptor cells by CRISPR-Cas9

Precursor messenger RNA (Pre-mRNA) splicing is an essential biological process in eukaryotic cells. Genetic mutations in many spliceosome genes confer human eye diseases. Mutations in the pre-mRNA splicing factor, RP9 (also known as PAP1), predispose autosomal dominant retinitis pigmentosa (adRP) wi...

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Detalles Bibliográficos
Autores principales:	Lv, Ji-Neng, Zhou, Gao-Hui, Chen, Xuejiao, Chen, Hui, Wu, Kun-Chao, Xiang, Lue, Lei, Xin-Lan, Zhang, Xiao, Wu, Rong-Han, Jin, Zi-Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317003/ https://www.ncbi.nlm.nih.gov/pubmed/28216641 http://dx.doi.org/10.1038/srep43062

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