The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells

Vascular endothelial cell growth factor receptor 2 (VEGFR2) is an essential receptor for the homeostasis of endothelial cells. In this study, we showed that NEDD8-conjugated Cullin3 (CUL3)-based ubiquitin E3 (UbE3) ligase plays a crucial role in VEGFR2 mRNA expression. Human umbilical vein endotheli...

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Detalles Bibliográficos
Autores principales: Sakaue, Tomohisa, Sakakibara, Iori, Uesugi, Takahiro, Fujisaki, Ayako, Nakashiro, Koh-ichi, Hamakawa, Hiroyuki, Kubota, Eiji, Joh, Takashi, Imai, Yu-ki, Izutani, Hironori, Higashiyama, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317005/
https://www.ncbi.nlm.nih.gov/pubmed/28216678
http://dx.doi.org/10.1038/srep42845

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