Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A

Suramin was previously shown to bind to the EV-A71 capsid through its naphthalenetrisulfonic acid groups, thereby reducing virus-cell binding and inhibiting viral replication. Here, we identify VP1-145 as the critical amino acid that accounts for the differential sensitivity of EVA-71 viruses to sur...

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Detalles Bibliográficos
Autores principales: Ren, Peijun, Zheng, Yimei, Wang, Wenqi, Hong, Liping, Delpeyroux, Françis, Arenzana-Seisdedos, Fernando, Altmeyer, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317167/
https://www.ncbi.nlm.nih.gov/pubmed/28218309
http://dx.doi.org/10.1038/srep42902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317167/
https://www.ncbi.nlm.nih.gov/pubmed/28218309
http://dx.doi.org/10.1038/srep42902

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