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Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study

Overexpression of the efflux pump P-glycoprotein (P-gp) is one of the important mechanisms of multidrug resistance (MDR) in many tumor cells. In this study, 26 novel 5-oxo-hexahydroquinoline derivatives containing different nitrophenyl moieties at C(4) and various carboxamide substituents at C(3) we...

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Detalles Bibliográficos
Autores principales:	Shahraki, Omolbanin, Edraki, Najmeh, Khoshneviszadeh, Mehdi, Zargari, Farshid, Ranjbar, Sara, Saso, Luciano, Firuzi, Omidreza, Miri, Ramin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317256/ https://www.ncbi.nlm.nih.gov/pubmed/28243063 http://dx.doi.org/10.2147/DDDT.S119995

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