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An in vivo mechanism for the reduced peripheral neurotoxicity of NK105: a paclitaxel-incorporating polymeric micellar nanoparticle formulation

In our previous rodent studies, the paclitaxel (PTX)-incorporating polymeric micellar nanoparticle formulation NK105 had showed significantly stronger antitumor effects and reduced peripheral neurotoxicity than PTX dissolved in Cremophor(®) EL and ethanol (PTX/CRE). Thus, to elucidate the mechanisms...

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Detalles Bibliográficos
Autores principales:	Nakamura, Iwao, Ichimura, Eiji, Goda, Rika, Hayashi, Hitomi, Mashiba, Hiroko, Nagai, Daichi, Yokoyama, Hirofumi, Onda, Takeshi, Masuda, Akira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317268/ https://www.ncbi.nlm.nih.gov/pubmed/28243090 http://dx.doi.org/10.2147/IJN.S114356

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