P2Y(12) receptor-mediated activation of spinal microglia and p38MAPK pathway contribute to cancer-induced bone pain

BACKGROUND: Cancer-induced bone pain (CIBP) is one of the most challenging clinical problems due to a lack of understanding the mechanisms. Recent evidence has demonstrated that activation of microglial G-protein-coupled P2Y(12) receptor (P2Y(12)R) and proinflammatory cytokine production play an imp...

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Detalles Bibliográficos
Autores principales: Liu, Mingjuan, Yao, Ming, Wang, Hanqi, Xu, Longsheng, Zheng, Ying, Huang, Bing, Ni, Huadong, Xu, Shijie, Zhou, Xuyan, Lian, Qingquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5317303/
https://www.ncbi.nlm.nih.gov/pubmed/28243146
http://dx.doi.org/10.2147/JPR.S124326

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