Rosiglitazone Metabolism in Human Liver Microsomes Using a Substrate Depletion Method

BACKGROUND: Elimination of rosiglitazone in humans is via hepatic metabolism. The existing studies suggest that CYP2C8 is the major enzyme responsible, with a minor contribution from CYP2C9; however, other studies suggest the involvement of additional cytochrome P450 enzymes and metabolic pathways....

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Detalles Bibliográficos
Autores principales: Bazargan, Maryam, Foster, David J. R., Davey, Andrew K., Muhlhausler, Beverly S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318334/
https://www.ncbi.nlm.nih.gov/pubmed/28074333
http://dx.doi.org/10.1007/s40268-016-0166-4

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