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Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome()()
Electric conductivity in plasma is the balance between oxidized and reduced molecules (static Oxidation-Reduction Potential, sORP) and the amount of readily oxidizable molecules (capacity ORP, cORP). Adults with metabolic syndrome (MetS) have increased inflammation, dyslipidemia and oxidative stress...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318349/ https://www.ncbi.nlm.nih.gov/pubmed/28222379 http://dx.doi.org/10.1016/j.redox.2017.02.010 |
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author | Bobe, Gerd Cobb, Tora J. Leonard, Scott W. Aponso, Savinda Bahro, Christopher B. Koley, Dipankar Mah, Eunice Bruno, Richard S. Traber, Maret G. |
author_facet | Bobe, Gerd Cobb, Tora J. Leonard, Scott W. Aponso, Savinda Bahro, Christopher B. Koley, Dipankar Mah, Eunice Bruno, Richard S. Traber, Maret G. |
author_sort | Bobe, Gerd |
collection | PubMed |
description | Electric conductivity in plasma is the balance between oxidized and reduced molecules (static Oxidation-Reduction Potential, sORP) and the amount of readily oxidizable molecules (capacity ORP, cORP). Adults with metabolic syndrome (MetS) have increased inflammation, dyslipidemia and oxidative stress; therefore, participants with MetS were hypothesized to have higher plasma sORP and lower cORP than those measures in healthy adults. Heparin-anticoagulated plasma from healthy and age- and gender-matched individuals with MetS (BMI: 22.6±0.7 vs. 37.7±3.0 kg/m(2), respectively) was collected in the fasting state at 0, 24, 48, and 72 h during each of four separate interventions in a clinical trial. At baseline, plasma sORP was 12.4% higher (P=0.007), while cORP values were less than half (41.1%, P=0.001) in those with MetS compared with healthy participants. An sORP >140 mV detected MetS with 90% sensitivity and 80% specificity, while a cORP <0.50 μC detected MetS with 80% sensitivity and 100% specificity. sORP and cORP values in participants with MetS compared with healthy adults were linked to differences in waist circumference and BMI; in plasma markers of dyslipidemia (triglycerides, HDL-cholesterol, and oxidized LDL-cholesterol) and inflammation (C-reactive protein, IL-10); as well as with urinary markers of lipid peroxidation (e.g., 2,3-dinor-5,6-dihydro-8-iso-PGF(2α); 2,3-dinor-8-iso-PGF(2α)). Higher sORP values are a robust indicator of metabolic stress, while lower cORP values act as an indicator of decreased metabolic resilience. |
format | Online Article Text |
id | pubmed-5318349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-53183492017-02-26 Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome()() Bobe, Gerd Cobb, Tora J. Leonard, Scott W. Aponso, Savinda Bahro, Christopher B. Koley, Dipankar Mah, Eunice Bruno, Richard S. Traber, Maret G. Redox Biol Research Paper Electric conductivity in plasma is the balance between oxidized and reduced molecules (static Oxidation-Reduction Potential, sORP) and the amount of readily oxidizable molecules (capacity ORP, cORP). Adults with metabolic syndrome (MetS) have increased inflammation, dyslipidemia and oxidative stress; therefore, participants with MetS were hypothesized to have higher plasma sORP and lower cORP than those measures in healthy adults. Heparin-anticoagulated plasma from healthy and age- and gender-matched individuals with MetS (BMI: 22.6±0.7 vs. 37.7±3.0 kg/m(2), respectively) was collected in the fasting state at 0, 24, 48, and 72 h during each of four separate interventions in a clinical trial. At baseline, plasma sORP was 12.4% higher (P=0.007), while cORP values were less than half (41.1%, P=0.001) in those with MetS compared with healthy participants. An sORP >140 mV detected MetS with 90% sensitivity and 80% specificity, while a cORP <0.50 μC detected MetS with 80% sensitivity and 100% specificity. sORP and cORP values in participants with MetS compared with healthy adults were linked to differences in waist circumference and BMI; in plasma markers of dyslipidemia (triglycerides, HDL-cholesterol, and oxidized LDL-cholesterol) and inflammation (C-reactive protein, IL-10); as well as with urinary markers of lipid peroxidation (e.g., 2,3-dinor-5,6-dihydro-8-iso-PGF(2α); 2,3-dinor-8-iso-PGF(2α)). Higher sORP values are a robust indicator of metabolic stress, while lower cORP values act as an indicator of decreased metabolic resilience. Elsevier 2017-02-14 /pmc/articles/PMC5318349/ /pubmed/28222379 http://dx.doi.org/10.1016/j.redox.2017.02.010 Text en © 2017 Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Paper Bobe, Gerd Cobb, Tora J. Leonard, Scott W. Aponso, Savinda Bahro, Christopher B. Koley, Dipankar Mah, Eunice Bruno, Richard S. Traber, Maret G. Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome()() |
title | Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome()() |
title_full | Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome()() |
title_fullStr | Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome()() |
title_full_unstemmed | Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome()() |
title_short | Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome()() |
title_sort | increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome()() |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318349/ https://www.ncbi.nlm.nih.gov/pubmed/28222379 http://dx.doi.org/10.1016/j.redox.2017.02.010 |
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